Obesity and the use of antibiotics and probiotics in rats

Chemotherapy
Fernando de Sá Del FiolLuciane Lopes Sant'Ana

Abstract

Obesity has become a major public health challenge in recent years. Recent studies suggest that alterations of the gut microbiota by antibiotics could play an important role in obesity. We investigated this topic using 60 Wistar rats, which were divided into 3 experimental groups: rats treated with amoxicillin, rats treated with amoxicillin plus Saccharomyces boulardii and controls. Treatments were administered over the course of 2 weeks. Tetrapolar bioelectric impedance analysis and anthropometric evaluations were conducted. The body mass index was significantly lower for the animals in the control group (p = 0.034). The same result was observed for the Lee index: the control group had a lower index than the 2 groups that received antibiotic treatment (p = 0.0019). The total body water data demonstrated that the control group had the greatest amount of body water (279.1 g, p = 0.0243). The groups treated with the antibiotic exhibited a greater accumulation of body fat than the control group.

Citations

Nov 23, 2016·Journal of Veterinary Internal Medicine·J S Weese, M Jelinski
Apr 17, 2018·Diabetes/metabolism Research and Reviews·Sandra Aparecida Dos ReisJosefina Bressan
Aug 28, 2015·The Journal of Clinical Endocrinology and Metabolism·Kristian Hallundbæk MikkelsenAnton Pottegård
Sep 8, 2020·International Journal of Epidemiology·Jinqiu YuanMichael Moore
Dec 19, 2018·Frontiers in Pharmacology·Fernando S Del FiolCristiane C Bergamaschi
Dec 12, 2020·Food Science of Animal Resources·Vijitra Luang-InNyuk Ling Ma
Jun 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lola Rueda-RuzafaPablo Roman
Nov 11, 2021·Pharmacological Reports : PR·Sandra Aparecida Dos Reis LouzanoMaria do Carmo Gouveia Peluzio

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