Obesity as a Key Factor Underlying Idiopathic Hyperaldosteronism

The Journal of Clinical Endocrinology and Metabolism
Youichi OhnoJPAS Study Group

Abstract

Recently, the relationship between primary aldosteronism (PA) and various metabolic disorders, including obesity, diabetes mellitus, and dyslipidemia, has been discussed. However, in PA, aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) have different etiologies. Our objectives were to clarify differences in obesity and metabolic disorders between APA and IHA and to gain insight in the pathogenesis of IHA. This is a retrospective cross-sectional study. We assessed the PA database established by the multicenter Japan Primary Aldosteronism Study. For comparative analysis, data were also collected from 274 patients with essential hypertension (EHT). We compared prevalences of obesity and metabolic disorders between patients with APA and patients with IHA. Comparisons with sex-, age-, and blood pressure-matched patients with EHT were also performed. Correlations between metabolic parameters and plasma aldosterone concentrations (PACs) in each subtype were analyzed. Analysis of 516 patients with APA and 1015 patients with IHA revealed PACs were significantly higher in patients with APA than patients with IHA. By contrast, after we adjusted for clinical backgrounds, the prevalence of obesity was significantl...Continue Reading

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Citations

Jun 25, 2019·Hypertension·Hiroshi AkasakaUNKNOWN Japan Primary Aldosteronism Study Group *
Apr 24, 2020·Clinical Endocrinology·Ryo NakamaruUNKNOWN JPAS/JRAS Study Group
May 31, 2020·Nature Communications·Julien WilsHervé Lefebvre
Oct 23, 2019·Journal of the Endocrine Society·Mitsuha MorisakiUNKNOWN JPAS Study Group
Feb 3, 2021·Journal of Human Hypertension·Moe Thuzar, Michael Stowasser
Mar 9, 2021·Clinical Endocrinology·Gregory Kline
Mar 5, 2021·Current Opinion in Nephrology and Hypertension·Gregory L HundemerAlexander A Leung
Mar 31, 2021·Blood Pressure·Arleen AuneEva Gerdts
Jul 4, 2021·Molecular and Cellular Endocrinology·Antoine-Guy LopezEstelle Louiset
Oct 23, 2021·Endocrinology and Metabolism·Mitsuhide NaruseMasakatsu Sone

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