Obesity as an aetiological factor in the development of osteoarthrosis

Gerontology
M Walton

Abstract

A quantitative survey was carried out on the subcutaneous and abdominal adipose tissue of two inbred strains of mouse; STR/ORT is a strain in which the knee joints of the males have a very high incidence of osteoarthrosis, whereas the incidence of the disease in the females is much lower; the CBA/ORT mice represent a normal laboratory strain which rarely suffers from osteoarthrosis. In terms of the weight of readily removable subcutaneous and abdominal adipose tissue, the male STR/ORT mice were slightly leaner than the male CBA/ORT mice, the female STR/ORT mice were obese when compared with their CBA/ORT counterparts. Thus, in these mice, there was no positive correlation between obesity and osteoarthrosis. This evidence confirms previous mouse studies and is contrary to the commonly held view that in humans obesity predisposes to osteoarthrosis.

Citations

Jul 15, 2015·Biomedical Reports·Kenichi KumagaiYoshiki Hamada
Oct 19, 2011·International Journal of Rheumatology·Riccardo ChiusaroliGianfranco Caselli
May 19, 2009·Experimental Animals·Kentaroo UchidaMoritoshi Itoman
Mar 14, 2014·Arthritis & Rheumatology·Blandine PouletAndrew A Pitsillides
Oct 13, 2007·Osteoarthritis and Cartilage·K JaegerB Mueller-Hilke
Mar 10, 2001·Osteoarthritis and Cartilage·R M MasonM T Bayliss
Dec 15, 2016·Osteoarthritis and Cartilage·K A StainesA A Pitsillides
Oct 1, 1979·Acta Orthopaedica Scandinavica·M Walton, M W Elves

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