Obesity associated advanced glycation end products within the human uterine cavity adversely impact endometrial function and embryo implantation competence

Human Reproduction
Gabriella S AntoniottiJemma Evans

Abstract

Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion. Obese women experience a higher incidence of infertility, recurrent miscarriage and pregnancy complications compared with lean women. Oocyte donation cycles suggest a detrimental uterine environment plays a role in these outcomes. Uterine lavage and tissues from lean (BMI 19.5-24.9, n = 17) and obese (BMI > 30, n = 16) women examined. Cell culture experiments utilizing human endometrial epithelial, trophectoderm and trophoblast cell lines and primary human stromal cells used to examine the functional impact of obese levels of AGEs. Levels of AGEs examined within uterine lavage assessed by ELISA to determine differences between lean and obese women. Expression and localization of AGEs, receptor for AGEs (RAGE) and NFκB within endometrial tissues obtained from lean a...Continue Reading

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Citations

Oct 16, 2018·Reproductive Sciences·Ivo BrosensGiuseppe Benagiano
Oct 18, 2018·The Journal of Obstetrics and Gynaecology Research·Lauren J EwingtonJan J Brosens
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Feb 9, 2021·The Journal of Reproduction and Development·Tatsuya NakanoTasuku Mitani
May 29, 2021·Reproductive Sciences·Nan-Xing Jiang, Xue-Lian Li

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