Obesity-associated T-cell and macrophage activation improve partly after a lifestyle intervention.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
I J B van der ZalmW A Dik

Abstract

The relation between low-grade inflammation and metabolic dysfunction in obesity is not fully explored. To evaluate immune parameters in the obese state and after a lifestyle intervention program. Patients with obesity (n = 87) from an academic obesity clinic were compared with controls with regard to macrophage and T-cell activation (reflected by serum levels of soluble CD163 (sCD163) and soluble IL-2 receptor (sIL-2R), respectively), and an array of cytokines, chemokines, and growth factors. In addition, these parameters and regulatory T-cells (Treg), were studied in 27 patients who followed a 75-week lifestyle intervention (dietary advice, exercise, and psychoeducation). Mean sIL-2R and sCD163 levels were higher in patients than controls (sIL-2R:2884 ± 936 pg/ml vs. 2207 ± 813 pg/ml, p = 0.001; sCD163:1279 ± 580 pg/ml vs. 661 ± 271 pg/ml, p < 0.0001 respectively). Patients with metabolic syndrome (MetS) had higher sCD163 than those without (1467 ± 656 pg/ml vs. 1103 ± 438 pg/ml). Patients had higher IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-15, IL-17A, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, G-CSF, GM-CSF, FGF, IFN-γ, and TNF-α than controls, whereas VEGF-A, PDGF-BB, and eotaxin were lower. Upon intervention...Continue Reading

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Citations

Dec 18, 2020·Frontiers in Nutrition·Daan L de FrelElisabeth F C van Rossum
Dec 10, 2020·Immunity & Ageing : I & a·Alistair V W NunnJimmy D Bell
May 17, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Vittoria D'EspositoPietro Formisano
Aug 28, 2021·Medicina·Natalia ZdanowskaAgnieszka Owczarczyk-Saczonek

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Methods Mentioned

BETA
ELISA
Assay
flowcytometry
FACS

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