Obesity: considerations about etiology, metabolism, and the use of experimental models.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Luciana Oquendo Pereira-LanchaAntonio H Lancha

Abstract

Studies have been conducted in order to identify the main factors that contribute to the development of obesity. The role of genetics has also been extensively studied. However, the substantial augmentation of obesity prevalence in the last 20 years cannot be justified only by genetic alterations that, theoretically, would have occurred in such a short time. Thus, the difference in obesity prevalence in various population groups is also related to environmental factors, especially diet and the reduction of physical activity. These aspects, interacting or not with genetic factors, could explain the excess of body fat in large proportions worldwide. This article will focus on positive energy balance, high-fat diet, alteration in appetite control hormones, insulin resistance, amino acids metabolism, and the limitation of the experimental models to address this complex issue.

Associated Clinical Trials

References

Jan 15, 1979·Biochemical and Biophysical Research Communications·A B Awad, E A Zepp
Sep 1, 1976·Physiology & Behavior·A Sclafani, D Springer
Nov 1, 1992·Seminars in Liver Disease·D J McNamara, W H Howell
Apr 1, 1988·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M GianottiA Palou
Feb 1, 1984·Metabolism: Clinical and Experimental·A GolayE Jéquier
Apr 1, 1994·Diabetes·J W HunnicuttJ M McDonald
Jun 1, 1996·Diabetologia·L H StorlienL V Campbell
Apr 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·N HaapanenI Vuori
Jun 20, 1998·Science·J O Hill, J C Peters
Apr 4, 2000·European Journal of Clinical Nutrition·C A MonteiroB M Popkin
Aug 10, 2000·The Journal of Biological Chemistry·E DuplusC Forest
Aug 2, 2001·Nature Medicine·A R Saltiel
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·P J EnglishJ P H Wilding
Jun 12, 2003·Metabolism: Clinical and Experimental·Samah HajamorAndré Tchernof
Sep 5, 2003·The New England Journal of Medicine·Rachel L BatterhamStephen R Bloom
Dec 4, 2003·Progress in Biophysics and Molecular Biology·Luciana Oquendo Pereira, Antonio Herbert Lancha
Jun 3, 2004·The Journal of Clinical Investigation·Soren NielsenMichael D Jensen
Jun 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Stephen E BorstGregory J Bagby
Aug 27, 2005·Diabetes Care·Harold E Lebovitz, Mary Ann Banerji
Sep 27, 2005·Physiological Reviews·Sarah StanleyStephen Bloom
Sep 5, 2006·Cell Metabolism·Rachel L BatterhamDominic J Withers

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Citations

Oct 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carolina Staut PinhalPatrícia Aline Boer
Aug 28, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Günter Müller
Aug 20, 2015·European Journal of Clinical Nutrition·C DrenowatzS N Blair
Feb 11, 2015·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Santiago Tavares PaesAna Eliza Andreazzi
Jan 15, 2014·Journal of Animal Science and Biotechnology·Caitlin A CooperSean D Owens
May 18, 2016·Annales de cardiologie et d'angéiologie·F AffaneM Y Lamri-Senhadji
Jan 13, 2017·Journal of the American College of Nutrition·Elena Rodríguez-RodríguezRosa M Ortega
Jul 31, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R M BaninM M Telles
Apr 6, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F A N MaksudA J A Barbosa
Aug 11, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·María Correa-RodríguezJacqueline Schmidt-RioValle
Sep 24, 2020·Phytotherapy Research : PTR·Meysam ZarezadehMehrangiz Ebrahimi Mamaghani
Apr 20, 2020·Experimental Physiology·Houda NashawiElizabeth G Mietlicki-Baase
Jul 6, 2020·Archives of Physiology and Biochemistry·Amir Hossein FaghfouriYaser Khaje Bishak
Apr 23, 2020·Animal Models and Experimental Medicine·Noriyuki KajiFumitoshi Asai
Mar 20, 2021·Diabetology & Metabolic Syndrome·Mariana de Moura E DiasFermín Ignacio Milagro
May 27, 2021·Antioxidants & Redox Signaling·Amaya Lopez-PascualPedro González-Muniesa
Sep 21, 2013·Lipids in Health and Disease·Uberdan Guilherme Mendes de CastroAndréia Carvalho Alzamora

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Methods Mentioned

BETA
glycosylation

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