Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Jeffrey D RoizenMichael A Levine

Abstract

Normal vitamin D homeostasis is critical for optimal health; nevertheless, vitamin D deficiency is a worldwide public health problem. Vitamin D insufficiency is most commonly due to inadequate cutaneous synthesis of cholecalciferol and/or insufficient intake of vitamin D, but can also arise as a consequence of pathological states such as obesity. Serum concentrations of 25(OH)D (calcidiol) are low in obesity, and fail to increase appropriately after vitamin D supplementation. Although sequestration of vitamin D in adipose tissues or dilution of ingested or cutaneously synthesized vitamin D in the large fat mass of obese patients has been proposed to explain these findings, here we investigate the alternative mechanism that reduced capacity to convert parent vitamin D to 25(OH)D due to decreased expression of CYP2R1, the principal hepatic vitamin D 25-hydroxylase. To test this hypothesis, we isolated livers from female mice of 6 to 24 weeks of age, weaned onto either a normal chow diet or a high-fat diet, and determined the abundance of Cyp2r1 mRNA using digital droplet-quantitative PCR. We observed a significant (p < 0.001) decrease in Cyp2r1 mRNA in the liver of high-fat diet-fed mice relative to lean-chow-fed female mice. Mor...Continue Reading

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Citations

May 9, 2019·Nutrients·Roberto CesareoAndrea Palermo
May 30, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jeffrey D Roizen, Michael A Levine
Oct 8, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger Bouillon, Dan Bikle
Nov 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Christine A SimpsonThomas O Carpenter
Apr 7, 2020·Current Osteoporosis Reports·Alexandra N Krez, Emily M Stein
May 30, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jean-François LandrierFranck Tourniaire
Oct 16, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R Bouillon, J M Quesada-Gomez
Jan 23, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L VerasH Fonseca
Sep 12, 2020·International Journal of Molecular Sciences·Federica SaponaroRiccardo Zucchi
Oct 14, 2020·European Journal of Pediatrics·Akshay TaydeAnuradha Rai
Dec 7, 2020·Annales d'endocrinologie·Antoine-Guy LopezRachel Desailloud
Jan 26, 2021·Royal Society Open Science·George GriffinDavid Thickett
Dec 10, 2020·American Journal of Respiratory Cell and Molecular Biology·Heejae HanJung-Won Park
Sep 14, 2020·Nutrition Research·Yang WangSue A Shapses
Apr 2, 2021·Current Obesity Reports·Irene KarampelaMaria Dalamaga
Jun 27, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karl MichaëlssonHåkan Melhus
Sep 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Rune HoltMartin Blomberg Jensen
Dec 17, 2021·Yonsei Medical Journal·Jung-Won Park
Nov 29, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Ashley J StoffersMichael A Levine

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