Obesity-driven alterations in adipose-derived stem cells are partially restored by weight loss

Obesity
Laura M PérezBeatriz G Gálvez

Abstract

The therapeutic potential of adipose-derived stem cells (ASCs) is reduced by various stress-inducing conditions that affect tissue homeostasis such as diabetes, aging, and obesity. Previous works have provided evidence of negative effects of obesity on ASC populations, but it is unclear whether this persists after a weight loss. This study evaluated whether weight loss can restore the attenuated properties found in ASCs derived from populations with obesity (oASCs). In vitro functional analyses were performed to investigate the possible recovery properties in mouse oASCs. Using ASCs isolated from subcutaneous tissue from formerly obese mice (dASCs) and control mice (cASCs), cell proliferation, viability, and some regenerative properties in these cells were analyzed compared with oASCs to evaluate the functional cell state. Cell proliferation, viability, and some regenerative properties are strengthened in dASCs and cASCs compared with oASCs. Nevertheless, metabolic analysis reveals a mitochondrial load misbalance and function leading to impaired respiration in dASCs. This study demonstrates that an initial obese environment triggers a detrimental state in ASCs that is not completely recovered after weight loss.

References

Mar 10, 2001·Cell·B M Spiegelman, J S Flier
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Karine ClémentDominique Langin
Mar 23, 2005·Biochemical and Biophysical Research Communications·Martin BrzoskaPatrick Baer
Jan 30, 2007·Journal of the American Chemical Society·Vasyl V ShynkarYves Mely
Mar 25, 2009·Neoplasia : an International Journal for Oncology Research·Rene RodriguezJavier García-Castro
Jul 31, 2010·Mediators of Inflammation·Carmela Rita BalistreriGiuseppina Candore
Jan 20, 2011·Journal of Translational Medicine·Anastasia EfimenkoAlexandra Stolzing
Feb 10, 2011·Nature Reviews. Molecular Cell Biology·Pankaj K MandalDerrick J Rossi
Apr 7, 2011·Maturitas·Blanca M HerreraCecilia M Lindgren
May 6, 2011·Stem Cells·Nuria San MartinBeatriz G Galvez
May 7, 2011·Archives of Physiology and Biochemistry·Nuria San Martín, Beatriz G Gálvez
Jul 1, 2011·Stem Cells International·Eduardo MansillaAlberto Maceira
Aug 19, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mar RoldanMiguel Martin
Jul 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Blanca OñateLina Badimon
Oct 30, 2012·Molecular Cell·Laura A Sena, Navdeep S Chandel
Dec 6, 2012·Aging·Francesca PintusAlessandro Rufini
Feb 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alessandra InsingaPier Giuseppe Pelicci
Feb 21, 2013·Diabetes·Laura M PérezBeatriz G Gálvez
May 16, 2013·Archives of Physiology and Biochemistry·Laura M PérezBeatriz G Gálvez
Jul 16, 2013·Cell Metabolism·Xiuling XuJuan Carlos Izpisua Belmonte
Oct 2, 2013·Human Heredity·Michael E SymondsAlexis C Frazier-Wood
Nov 7, 2013·Stem Cells International·Abhishek Sohni, Catherine M Verfaillie
Feb 22, 2014·Stem Cells Translational Medicine·George K SándorJuha Öhman
Mar 22, 2014·Nature Reviews. Molecular Cell Biology·Keisuke Ito, Toshio Suda
Jun 24, 2014·American Heart Journal·Emerson C PerinFrancisco Fernández-Avilés

❮ Previous
Next ❯

Citations

Mar 10, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·F LouwenJ Yuan
Jul 18, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A RitterJ Yuan
Sep 8, 2018·Journal of Cellular Physiology·Hanél Sadie-Van Gijsen
Jul 4, 2019·Aesthetic Plastic Surgery·Krishna S VyasKarim Bakri
May 30, 2020·Journal of Cellular Physiology·Laura M PérezBeatriz G Gálvez
May 27, 2020·Bioscience Reports·Sunhye ShinYuwei Jiang
Sep 29, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Miriam EjarqueSonia Fernández-Veledo
Apr 6, 2019·World Journal of Stem Cells·Karina Ribeiro Silva, Leandra Santos Baptista
Apr 6, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xueying ChenYanbing Li
Jun 18, 2021·Frontiers in Nutrition·Marianthi KalafatiMartina Kutmon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.