Obesity enhances eosinophilic inflammation in a murine model of allergic asthma.

British Journal of Pharmacology
M C CalixtoE Antunes

Abstract

Obesity is associated with deterioration in asthma outcomes. Although airways eosinophil accumulation is characteristic of lung allergic diseases, little is known about the influence of obesity on the allergic eosinophil trafficking from bone marrow to lung tissues, and recruitment to airways lumen. Here, we have assessed the effects of diet-induced obesity on allergic eosinophilic inflammation in mice, examining eosinophil trafficking from bone marrow to airways, and production of T(H)1/T(H)2 cytokines. C57BL/6 mice fed for 10 weeks with standard chow or high-fat diet were sensitized and challenged with ovalbumin. At 24-96 h post-ovalbumin challenge, bronchoalveolar lavage (BAL) fluid, lung tissue and bone marrow were examined. The high-fat-fed mice exhibited increased body weight and epididymal fat, glucose intolerance and alterations in lipid profile compared with the lean mice. Obesity markedly elevated serum leptin and lowered adiponectin levels. Ovalbumin challenge in obese mice promoted a markedly higher eosinophil accumulation in bone marrow and connective tissue surrounding the bronchial and bronchiolar segments. Eosinophil number in BAL fluid of obese mice was lower at 24 and 48 h. Levels of interleukin (IL)-5, eotaxi...Continue Reading

References

Sep 1, 1987·The Journal of Allergy and Clinical Immunology·G J GleichL P Kravis
May 1, 1995·Metabolism: Clinical and Experimental·R S SurwitM Rebuffé-Scrive
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·T T KungR W Chapman
Apr 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C KipsR A Pauwels
Dec 1, 1996·Metabolism: Clinical and Experimental·S IkemotoO Ezaki
Mar 1, 1997·The Journal of Clinical Investigation·A W MouldP S Foster
Jun 25, 1998·American Journal of Respiratory Cell and Molecular Biology·L J WoodP M O'Byrne
Apr 5, 2000·The Journal of Clinical Investigation·H Z ShiP F Weller
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·C M LillyE Israel
Feb 28, 2002·British Journal of Pharmacology·David J MacEwan
Mar 6, 2002·British Journal of Pharmacology·Letícia LintomenP Xavier Elsas
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Lorna J WoodPaul M O'Byrne
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Katherine EspositoDario Giugliano
Jun 10, 2003·Journal of Applied Physiology·S A ShoreR A Johnston
Sep 13, 2003·Chest·Carey Conley ThomsonUNKNOWN MARC Investigators
Nov 19, 2003·Current Opinion in Lipidology·Noriyuki OuchiKenneth Walsh
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Feb 18, 2004·Journal of Applied Physiology·Y M Rivera-SanchezS A Shore
Aug 12, 2004·Respiratory Medicine·H TatenoK Yamaguchi
Sep 14, 2004·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Michael J H AkermanMary K Madsen
Nov 2, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard A JohnstonStephanie A Shore
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Stephanie A ShoreRichard A Johnston
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
May 24, 2005·Nature Immunology·Scott T Weiss
Jul 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard A JohnstonStephanie A Shore
Sep 1, 2005·Clinical Reviews in Allergy & Immunology·Aysefa DoganciSusetta Finotto
Nov 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Abu R VasudevanChristie M Ballantyne
Nov 22, 2005·Pharmacology & Therapeutics·Stephanie A Shore, Richard A Johnston
Dec 24, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Frank L LuStephanie A Shore
Jan 13, 2006·British Journal of Pharmacology·James E Pease, Timothy J Williams
Mar 2, 2006·The European Respiratory Journal·M Peters-GoldenJ M Edelman
Mar 23, 2006·Annual Review of Immunology·Marc E Rothenberg, Simon P Hogan
Apr 22, 2006·American Journal of Respiratory and Critical Care Medicine·David A BeutherE Rand Sutherland
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
May 2, 2007·British Journal of Pharmacology·C PalmqvistP Bradding
May 8, 2007·The Journal of Allergy and Clinical Immunology·Helene F RosenbergPaul S Foster
May 8, 2007·The Journal of Allergy and Clinical Immunology·Susumu NakaeStephen J Galli
Jul 21, 2007·American Journal of Respiratory and Critical Care Medicine·Richard A JohnstonStephanie A Shore
Aug 23, 2007·Obesity·Catherine Gallou-KabaniClaudine Junien
Nov 27, 2007·The Journal of Allergy and Clinical Immunology·Christopher BrightlingYassine Amrani
Apr 4, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Simon P HoganMarc E Rothenberg
Apr 15, 2008·The Journal of Allergy and Clinical Immunology·Stephanie A Shore
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Galgani, E Ravussin

❮ Previous
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Citations

Dec 14, 2011·Immunologic Research·Kitty P CheungJulie M Jameson
May 23, 2012·Pulmonary Pharmacology & Therapeutics·Olga SidelevaAnne E Dixon
Jun 19, 2013·BMC Pulmonary Medicine·Milena Baptistella GrottaEdson Antunes
Jan 18, 2012·Cardiovascular Diabetology·Priscila F MonteiroEdson Antunes
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Dhananjay DesaiChris E Brightling
May 17, 2014·American Journal of Respiratory and Critical Care Medicine·Gudrun S MarijsseDominique M A Bullens
Jun 13, 2014·American Journal of Respiratory and Critical Care Medicine·Yueh-Ying HanJuan C Celedón
Jun 20, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Rie YamamotoJunichi Chihara
Nov 14, 2015·Expert Review of Respiratory Medicine·Laura De FerrariGiorgio Walter Canonica
Nov 4, 2015·Nutrition·Letícia Tamie Paiva YamadaAdaliene Versiani Matos Ferreira
Jan 12, 2013·Toxicology and Applied Pharmacology·Susan C TiltonRichard A Corley
Jul 5, 2011·Drug Discovery Today·Anthony M HolmesStephen T Holgate
Feb 1, 2013·Thrombosis and Haemostasis·Jindrich ChmelarTriantafyllos Chavakis
Jan 3, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L-P Boulet
Oct 10, 2013·Journal of Applied Toxicology : JAT·Rie YanagisawaHirohisa Takano
Oct 12, 2013·Journal of Cellular Biochemistry·O Sideleva, A E Dixon
Oct 18, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L-P Boulet
Oct 30, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C ElmoseS F Thomsen
Apr 25, 2015·Nature Reviews. Immunology·Valerie JuliaDavid Dombrowicz
Apr 2, 2011·Respiratory Physiology & Neurobiology·Simone A SaraivaPatricia R M Rocco
Dec 3, 2014·Metabolism: Clinical and Experimental·Luiz O S LeiriaMário J A Saad
Feb 18, 2016·American Journal of Respiratory Cell and Molecular Biology·Anne E Dixon, Matthew E Poynter
May 15, 2016·The Journal of Allergy and Clinical Immunology·Laetitia EveraereAnne Tsicopoulos
Jun 12, 2016·Developmental and Comparative Immunology·Claudio ProcacciniGiuseppe Matarese
Jun 28, 2016·International Immunopharmacology·Diana Majolli AndréEdson Antunes
May 11, 2016·American Journal of Respiratory Cell and Molecular Biology·Benjamin T Suratt
Sep 7, 2016·The Journal of Allergy and Clinical Immunology·Herman T den DekkerLiesbeth Duijts
Feb 6, 2018·Current Pharmacology Reports·Everett K HenryMark C Siracusa
Nov 28, 2017·Allergy·N SharmaR L Rabin
Sep 8, 2017·Immunology·Laetitia EveraereAnne Tsicopoulos
Apr 14, 2011·Nutrition Research and Practice·Hyun-Jung KimMyoung-Sool Do
Oct 22, 2013·Yonsei Medical Journal·Sun Hee JungJung Yeon Shim
May 21, 2014·Allergy, Asthma & Immunology Research·Sang-Ha KimErwin W Gelfand
Apr 19, 2018·The Korean Journal of Internal Medicine·Lin LiangSook Young Lee
Apr 29, 2015·Expert Review of Clinical Immunology·Jennifer L AtherAnne E Dixon
Nov 26, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Rodrigo Rodrigues E-LacerdaYanira Riffo-Vasquez
Dec 7, 2019·Nutrients·Rodrigo Rodrigues E-LacerdaGabriel Forato Anhê
Jan 5, 2020·Expert Review of Respiratory Medicine·Diego BagnascoGiorgio Walter Canonica
Mar 15, 2020·Journal of Leukocyte Biology·Gina N CalcoZhenying Nie

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