Obesity: global epidemiology and pathogenesis

Nature Reviews. Endocrinology
Matthias Blüher

Abstract

The prevalence of obesity has increased worldwide in the past ~50 years, reaching pandemic levels. Obesity represents a major health challenge because it substantially increases the risk of diseases such as type 2 diabetes mellitus, fatty liver disease, hypertension, myocardial infarction, stroke, dementia, osteoarthritis, obstructive sleep apnoea and several cancers, thereby contributing to a decline in both quality of life and life expectancy. Obesity is also associated with unemployment, social disadvantages and reduced socio-economic productivity, thus increasingly creating an economic burden. Thus far, obesity prevention and treatment strategies - both at the individual and population level - have not been successful in the long term. Lifestyle and behavioural interventions aimed at reducing calorie intake and increasing energy expenditure have limited effectiveness because complex and persistent hormonal, metabolic and neurochemical adaptations defend against weight loss and promote weight regain. Reducing the obesity burden requires approaches that combine individual interventions with changes in the environment and society. Therefore, a better understanding of the remarkable regional differences in obesity prevalence an...Continue Reading

References

May 1, 1976·Acta paediatrica Scandinavica·M Börjeson
May 24, 1990·The New England Journal of Medicine·C BouchardG Fournier
May 24, 1990·The New England Journal of Medicine·A J StunkardG E McClearn
Jan 1, 1989·The American Journal of Clinical Nutrition·J M McGinnis, M Nestle
Nov 1, 1969·The American Journal of Physiology·D L Coleman, K P Hummel
Sep 16, 1999·The New England Journal of Medicine·I S FarooqiS O'Rahilly
Apr 15, 2000·Nature·P G Kopelman
Jul 21, 2000·The Journal of Clinical Investigation·I S FarooqiS O'Rahilly
Jul 19, 2001·Annals of Human Biology·S J Ulijaszek
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Kevin R FontaineDavid B Allison
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Frank B HuJoAnn E Manson
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Matthias B SchulzeFrank B Hu
May 24, 2005·BMJ : British Medical Journal·John J ReillyUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Dec 22, 2006·The British Journal of Nutrition·F HayashiN Yoshiike
Feb 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·P KopelmanB Butland
Sep 1, 2007·American Journal of Public Health·Carlos A MonteiroBarry M Popkin
Apr 25, 2008·BMC Public Health·Ramón A Durazo-ArvizuTerrence Forrester
Jun 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Jane WardleRobert Plomin
Mar 21, 2009·The Milbank Quarterly·Kelly D Brownell, Kenneth E Warner
Apr 17, 2009·The American Journal of Clinical Nutrition·Boyd A SwinburnEric Ravussin
Oct 16, 2009·The American Journal of Clinical Nutrition·Marian Tanofsky-KraffJack A Yanovski
Oct 16, 2009·The American Journal of Clinical Nutrition·Boyd SwinburnEric Ravussin
Nov 20, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A M Sharma, R Padwal
Feb 16, 2010·American Journal of Preventive Medicine·Susan M Krebs-SmithClaire Bosire
Mar 27, 2010·Public Health Nutrition·Sandra Plachta-DanielzikManfred James Müller
Jul 10, 2010·International Journal of Environmental Research and Public Health·Ruth S M Chan, Jean Woo
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Oct 27, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B RokholmT I A Sørensen
Dec 3, 2010·The New England Journal of Medicine·Amy Berrington de GonzalezMichael J Thun
Jun 24, 2011·The New England Journal of Medicine·Dariush MozaffarianFrank B Hu
Aug 30, 2011·Lancet·Boyd A SwinburnSteven L Gortmaker
Oct 14, 2011·The American Journal of Clinical Nutrition·Vasanti S Malik, Frank B Hu

❮ Previous
Next ❯

Citations

Jul 19, 2019·BMJ : British Medical Journal·John P H WildingRichard Pile
Jul 30, 2019·Expert Review of Gastroenterology & Hepatology·Marco ArreseJuan Pablo Arab
Nov 23, 2019·Molecular Omics·J MolendijkM M Hill
Nov 27, 2019·Medicina·Adriana Florinela CӑtoiAndra Diana Andreicuț
Dec 31, 2019·PLoS Medicine·Dan ChaltielEmmanuelle Kesse-Guyot
Dec 1, 2019·Nature Reviews. Endocrinology·Charoula K NikolaouMichael E J Lean
Aug 25, 2019·Nutrients·Marja-Riitta TaskinenJan Borén
Jan 23, 2020·Nutrients·Daniela CiobârcăGianina Crișan
Feb 27, 2020·Advanced Healthcare Materials·Shantanu PradhanJohn H Slater
Mar 3, 2020·Nutrition Research Reviews·Ericka Moreno-MendezMaria-Luisa Lazo-de-la-Vega-Monroy
Feb 20, 2020·Nutrients·Patricia Seoane-CollazoCristina Contreras
Mar 20, 2020·Journal of Medicinal Food·Jeongmin Lee
Mar 8, 2020·Biomolecules·Eun Roh, Min-Seon Kim
Jan 18, 2020·Annual Review of Food Science and Technology·Qixing NieMingyong Xie
Mar 5, 2020·Endocrine Reviews·Matthias Blüher
Apr 9, 2020·Toxins·Thomas EbertPeter Stenvinkel
Apr 15, 2020·Journal of Clinical Medicine·Ana de HollandaÁngel Rebollo
May 5, 2020·European Eating Disorders Review : the Journal of the Eating Disorders Association·Kerstin BauerIsabelle Mack
May 19, 2020·Upsala Journal of Medical Sciences·Sobia Rana, Maha Mobin
May 22, 2020·Circulation Research·Marie-Eve PichéJean-Pierre Després
Jun 4, 2020·Journal of Developmental Origins of Health and Disease·Luana Lopes SouzaPatricia Cristina Lisboa
Jun 13, 2020·The Journal of International Medical Research·Xiaolin LiQi Zeng
Jun 24, 2020·Journal of Applied Physiology·Frédéric DutheilValentin Navel
Jun 26, 2020·Journal of Obesity & Metabolic Syndrome·Ga Eun NamUNKNOWN Korean Society for the Study of Obesity
Feb 27, 2020·Medicine and Science in Sports and Exercise·Samarmar ChacarounSamuel Verges
Oct 2, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Xiaojie GongDongmei Xu
Jul 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ilavenil SoundharrajanKi Choon Choi
Jul 15, 2020·Biotechnology Journal·Yvonne Yijuan LimDelicia Shu Qin Ooi
Jun 11, 2019·Phytotherapy Research : PTR·Angelo A Izzo

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Related Papers

Current Opinion in Gastroenterology
Adrian J Park, Stephen R Bloom
Nature Reviews. Endocrinology
Christian F Rueda-ClausenArya M Sharma
World Journal of Diabetes
Joseph M Pappachan, Ananth K Viswanath
© 2022 Meta ULC. All rights reserved