PMID: 16613817Apr 15, 2006Paper

Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges

Hormones : International Journal of Endocrinology and Metabolism
Antje KörnerW Kiess

Abstract

Body weight is regulated by a feedback loop in which peripheral signals report nutritional information to an integratory center in the brain. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centered in the hypothalamus. In recent years a number of additional signaling molecules secreted by adipose tissue have been discovered. These hormones, named adipocytokines, include resistin, adiponectin, and visfatin. Among the adipocytokines, adiponectin is perhaps the most interesting compound for the clinician since low adiponectin serum levels have been found in obese subjects and in particular in insulin resistant subjects. The definition and diagnosis of obesity in children and adolescents are surprisingly difficult. The level of fatness at which morbidity increases is determined on an acturial basis. In children and adolescents the degree of body fat mass depends upon ethnic background , gender, developmental stage, and age. Treatment and prevention of obesity in childhood and adolescence are major challenges for today's health care providers and societies.

Citations

Mar 11, 2009·European Journal of Endocrinology·Sonali PechlivanisAsta Försti
Feb 22, 2012·European Journal of Pediatrics·Kwok-Kei Mak, Sharon H Tan
Apr 13, 2010·Molecular and Cellular Endocrinology·T Delessa ChallaE Monsonego Ornan
May 20, 2011·Annales d'endocrinologie·D GauvreauK Cianflone
Aug 7, 2013·Orvosi hetilap·Miklós Fodor, Gyula Sófi
Nov 6, 2010·Journal of Obesity·Jie MiKatherine Cianflone
Sep 16, 2011·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Reinhard W HollSusanna Wiegand
Jun 30, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Artur BossowskiBeata Zelazowska-Rutkowska
Oct 7, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J Amuzie, James J Pestka
May 20, 2020·Allergy·Juan José Nieto-FontarigoFrancisco Javier Salgado
May 4, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nádia BritoAlice Mirante
Dec 31, 2011·The Journal of Biological Chemistry·Tenagne Delessa ChallaChristian Wolfrum
Dec 17, 2017·The Journal of Pediatrics·Gali ZabarskyRam Weiss

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