Obesity-induced discrepancy between contractile and metabolic phenotypes in slow- and fast-twitch skeletal muscles of female obese Zucker rats

Journal of Applied Physiology
Luz M AcevedoJosé-Luis L Rivero

Abstract

A clear picture of skeletal muscle adaptations to obesity and related comorbidities remains elusive. This study describes fiber-type characteristics (size, proportions, and oxidative enzyme activity) in two typical hindlimb muscles with opposite structure and function in an animal model of genetic obesity. Lesser fiber diameter, fiber-type composition, and histochemical succinic dehydrogenase activity (an oxidative marker) of muscle fiber types were assessed in slow (soleus)- and fast (tibialis cranialis)-twitch muscles of obese Zucker rats and compared with age (16 wk)- and sex (females)-matched lean Zucker rats (n = 16/group). Muscle mass and lesser fiber diameter were lower in both muscle types of obese compared with lean animals even though body weights were increased in the obese cohort. A faster fiber-type phenotype also occurred in slow- and fast-twitch muscles of obese rats compared with lean rats. These adaptations were accompanied by a significant increment in histochemical succinic dehydrogenase activity of slow-twitch fibers in the soleus muscle and fast-twitch fiber types in the tibialis cranialis muscle. Obesity significantly increased plasma levels of proinflammatory cytokines but did not significantly affect pro...Continue Reading

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Citations

Jul 28, 2017·Journal of Neurophysiology·Christopher W MacDonellPhillip F Gardiner
Nov 15, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chad R StraightMark S Miller
Jan 29, 2020·The Journal of Experimental Biology·Guy A M MessaHans Degens
Apr 22, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bruna Aléxia Cristofoletti GrilloAdriano P Ciena
Jun 1, 2021·The Journal of Veterinary Medical Science·Yoshihiro WakayamaKazuho Honda

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