PMID: 16514174Mar 4, 2006Paper

Obesity-induced hypertension develops in young rats independently of the renin-angiotensin-aldosterone system

Experimental Biology and Medicine
Anita D SmithAnne McLaren Dorrance

Abstract

A correlation exists between obesity and hypertension. In the currently available models of diet-induced obesity, the treatment of rats with a high fat (HF) diet does not begin until adulthood. Our aim was to develop and characterize a model of pre-pubescent obesity-induced hypertension. Male Sprague-Dawley rats were fed a HF diet (35% fat) for 10 weeks, beginning at age 3 weeks. Blood pressure was measured by tail-cuff, and a terminal blood sample was obtained to measure fasting blood glucose, insulin, plasma renin, aldosterone, thiobarbitutic acid reactive substances (TBARS), and free 8-isoprostanes levels. The vascular reactivity in the aorta was assessed using a myograph. Blood pressure was increased in rats fed the HF diet (HF, 161 +/- 2 mm Hg vs. control, 137 +/- 2 mm Hg, P < 0.05). Blood glucose (HF, 155 +/- 4 mg/dL vs. control, 123 +/- 5 mg/dL, P < 0.05), insulin (HF, 232 +/- 63 pM vs. control, 60 +/- 11 pM, P < 0.05), TBARS (expressed as nM of malondialdehyde [MDA]/ml [HF, 1.8 +/- 0.37 nM MDA/ml vs. control 1.05 +/- 0.09 nM MDA/ml, P < 0.05]), and free 8-isoprostanes (HF, 229 +/- 68 pg/ml vs. control, 112 +/- 9 pg/ml, P < 0.05) levels were elevated in the HF diet group. Interestingly, plasma renin and aldosterone level...Continue Reading

References

Nov 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M D LogranoC Galli
Sep 1, 1995·Obesity Research·Y MatsuzawaK Tokunaga
Feb 1, 1996·Clinical and Experimental Hypertension : CHE·S N Iyer, M J Katovich
Nov 1, 1996·Hypertension·D RizzoniE Agabiti-Rosei
Feb 13, 1999·European Journal of Pharmacology·J DuarteA Zarzuelo
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T L GoodfriendD E Kelley
Jan 25, 2000·Circulation·O A Carretero, S Oparil
Apr 25, 2000·Hypertension·A D DobrianT J Lauterio
Mar 7, 2001·Hypertension·A D DobrianR L Prewitt
Mar 22, 2001·Kidney International·N KambhamV D D'Agati
Jun 19, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G AndronicoG Cerasola
Dec 12, 2001·JAMA : the Journal of the American Medical Association·R S Strauss, H A Pollack
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sumangala P RaoStephen E DiCarlo
Dec 20, 2002·Obesity Research·Alessandra Nunes FariaMaria Teresa Zanella
Feb 18, 2003·Current Opinion in Nephrology and Hypertension·John E HallLakshmi Tallam
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·M Ehrhart-BornsteinS R Bornstein
Jan 30, 2004·Recent Progress in Hormone Research·Ashish AnejaJames R Sowers
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Apr 16, 2005·American Journal of Hypertension·Yiqiang ZhouMong-Heng Wang
Apr 19, 2005·Journal of Hypertension·Ayotunde S O AdeagboMabayoje A Oriowo

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Citations

Dec 17, 2011·Journal of Applied Physiology·Joris van DrongelenMarc E A Spaanderman
Mar 12, 2013·International Journal of Hypertension·Takuya Kishi, Yoshitaka Hirooka
Mar 11, 2011·Clinical and Experimental Pharmacology & Physiology·Katsuyuki Ando, Megumi Fujita
Jul 27, 2011·Revista do Colégio Brasileiro de Cirurgiões·Antonio Carlos ValeziMariano de Almeida Menezes
May 1, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie W WattsGregory D Fink

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