Abstract
The purpose of this study was to assay the role of beta-adrenergic receptor signaling in the regulation of obesity-induced p53 in high fat feeding obese rats. The role of beta-adrenergic receptor/cyclic AMP in the regulation of p53 and its downstream mediators was evaluated by western blot and real-time quantitative RT-PCR among diet induced rats. Beta-adrenergic receptor agonist, isoproterenol, and an adenylate cyclase activator, forskolin, at a single dose significantly reduced insulin resistance consistent with a decrease in total and phospho-p53 levels in insulin and non-insulin metabolic target tissues. The decrease of p53 signaling was consistent with the elevation of AKT and subsequent activation. Obese rats exposed to fasting also exhibited improvement in insulin action despite a slight effect on p53 level. Results of the present study obviously showed that beta-adrenergic receptor agonist/cAMP prevented obesity-induced p53 activation. Although this effect in metabolic insulin target tissues tempted us to consider them as insulin sensitizers in obesity-related diabetes, p53 inhibition in non-insulin target tissues warned about the impairment of anti-cancer mechanisms in obese subjects.
References
Oct 1, 1994·Cellular Immunology·G P BaumanT L Roszman
May 1, 1994·Archives of General Psychiatry·R C VeithE R Peskind
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Jirí HrebícekLudek Cízek
May 8, 2003·The Journal of Biological Chemistry·Naoya YahagiNobuhiro Yamada
Apr 27, 2004·Revue D'épidémiologie Et De Santé Publique·M AlgaziM G Lê
Sep 8, 2006·Trends in Endocrinology and Metabolism : TEM·Andrew G RenehanAllan Flyvbjerg
Feb 15, 2008·Diabetes Care·Michael H ShanikJesse Roth
Apr 11, 2008·Nature Reviews. Molecular Cell Biology·Adilson GuilhermeMichael P Czech
May 16, 2009·Current Hypertension Reports·Alexandre A da SilvaJohn E Hall
May 20, 2009·Blood·Elin Hallan NaderiSoheil Naderi
Sep 1, 2009·Nature Medicine·Tohru MinaminoIssei Komuro
Jul 14, 2010·FEBS Letters·Majid SafaParisa Hayat
Dec 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven W Cole, Anil K Sood
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Brian A Hemmings, David F Restuccia
Feb 2, 2013·Current Medical Research and Opinion·Matteo MonamiEdoardo Mannucci
Nov 7, 2013·BMC Genomics·Michael SchuppAndreas Prokesch
Jan 7, 2014·Oncotarget·Jennifer K WolterMeredith S Irwin
Mar 8, 2014·Cell Biology International·Jyothi Kumari PosaB S Lakshmi
Jun 15, 2014·Nucleic Acids Research·Jayne LougheryDavid W Meek
Jul 13, 2014·General and Comparative Endocrinology·Reza HomayounfarHamid Zand
Aug 19, 2014·Lancet·Peter T Campbell
Oct 10, 2014·International Journal of Applied & Basic Medical Research·Kanwal Mohinder Dev Singh PanagGitanjali Goyal
Dec 20, 2014·Archives of Biochemistry and Biophysics·Arman GhorbaniHamid Zand
Citations
Mar 31, 2017·Biogerontology·Dinh-Toi Chu, Yang Tao
Dec 21, 2016·SpringerPlus·Elham EhrampoushSeyed Amin Kouhpayeh
Feb 15, 2017·Oxidative Medicine and Cellular Longevity·Justyna StrycharzAgnieszka Sliwinska
Sep 6, 2018·International Journal of Molecular Sciences·Jelena KrsticAndreas Prokesch
Oct 12, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Durgesh KumarAnil N Gaikwad
Mar 21, 2018·Scientific Reports·Alireza GhaemiReza Homayounfar
Jan 2, 2021·International Journal of Molecular Sciences·Masaki KimuraHidetsugu Saito
Jul 1, 2020·Endocrine Regulations·Alireza AskariReza Alipoor