Obesity influences white matter integrity in schizophrenia

Psychoneuroendocrinology
Marco SpangaroFrancesco Benedetti

Abstract

White matter (WM) alterations have been consistently described in patients with schizophrenia and correlated with the severity of psychotic symptoms and cognitive impairment. Obesity has been reported in over 40% of patients with schizophrenia and has been associated with cognitive deficits, cardiovascular diseases, metabolic alterations, and overall mortality. Moreover, studies among healthy subjects and subjects at risk for psychosis reported an influence of Body Mass Index (BMI) on structural connectivity. We therefore hypothesized that obesity and overweight could further disrupt WM integrity of patients affected by schizophrenia. Eighty-eight schizophrenia patients were evaluated for BMI. We divided the sample in overweight/obese and normal weight groups. We then performed whole brain tract-based spatial statistics in the WM skeleton with threshold-free cluster enhancement of DTI measures of WM microstructure: axial (AD), radial (RD), and mean diffusivity (MD), and fractional anisotropy (FA). A significant difference between the two groups was observed: normal weight patients showed higher AD and a higher FA trend compared to obese patients in several fibers' tracts including longitudinal fasciculus, uncinate fasciculus, c...Continue Reading

Citations

Oct 18, 2019·European Archives of Psychiatry and Clinical Neuroscience·Sophia KoganDavid Kimhy
Apr 3, 2020·Nature Communications·Feng ZhuXiancang Ma
Jan 24, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mustapha BouhraraRichard G Spencer
Jul 26, 2021·Journal of Psychiatric Research·Marco SpangaroRoberto Cavallaro
Oct 10, 2021·Human Brain Mapping·Dani BeckLars T Westlye

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