Obesity is a risk factor for developing critical condition in COVID-19 patients: A systematic review and meta-analysis

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
Mária FöldiKETLAK Study Group

Abstract

The disease course of COVID-19 varies from asymptomatic infection to critical condition leading to mortality. Identification of prognostic factors is important for prevention and early treatment. We aimed to examine whether obesity is a risk factor for the critical condition in COVID-19 patients by performing a meta-analysis. The review protocol was registered onto PROSPERO (CRD42020185980). A systematic search was performed in five scientific databases between 1 January and 11 May 2020. After selection, 24 retrospective cohort studies were included in the qualitative and quantitative analyses. We calculated pooled odds ratios (OR) with 95% confidence intervals (CIs) in meta-analysis. Obesity was a significant risk factor for intensive care unit (ICU) admission in a homogenous dataset (OR = 1.21, CI: 1.002-1.46; I2 = 0.0%) as well as for invasive mechanical ventilation (IMV) (OR = 2.05, CI: 1.16-3.64; I2 = 34.86%) in COVID-19. Comparing body mass index (BMI) classes with each other, we found that a higher BMI always carries a higher risk. Obesity may serve as a clinical predictor for adverse outcomes; therefore, the inclusion of BMI in prognostic scores and improvement of guidelines for the intensive care of patients with eleva...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 7, 2003·Annals of Internal Medicine·Anna PeetersUNKNOWN NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group
Mar 22, 2006·Annals of Internal Medicine·Jill A HaydenClaire Bombardier
Feb 4, 2009·Intensive Care Medicine·Charles W HogueDale M Needham
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Apr 5, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L FezeuS Czernichow
May 2, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R Huttunen, J Syrjänen
Jan 1, 2004·Research on Aging·Roland J Thorpe, Kenneth F Ferraro
Sep 12, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Qishi ZhengHongyan Diao
May 24, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gino Seravalle, Guido Grassi
Aug 8, 2018·The Journal of Infectious Diseases·Hannah E MaierAubree Gordon
May 28, 2019·Frontiers in Immunology·Rebekah Honce, Stacey Schultz-Cherry
Jan 11, 2020·Frontiers in Microbiology·Christine BourgeoisOlivier Lambotte
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Mar 7, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Mary A Lake
Mar 20, 2020·JAMA : the Journal of the American Medical Association·Matt ArentzMelissa Lee
Mar 24, 2020·JAMA : the Journal of the American Medical Association·Graziano OnderSilvio Brusaferro
Mar 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas C HanffAmir M Mohareb
Mar 29, 2020·The European Respiratory Journal·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 7, 2020·Acta Diabetologica·Livio Luzi, Maria Grazia Radaelli
Apr 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer LighterAnna Stachel
Apr 10, 2020·Obesity·Arthur SimonnetUNKNOWN LICORN and the Lille COVID-19 and Obesity study group
Apr 10, 2020·The Lancet. Respiratory Medicine·Jason PhuaUNKNOWN Asian Critical Care Clinical Trials Group
Apr 22, 2020·Obesity·Cyrielle CaussyEmmanuel Disse
Apr 22, 2020·Obesity·Alexis Elias MalavazosGianluca Iacobellis
Apr 29, 2020·Clinical Obesity·Nick FinerJens M Bruun
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
May 1, 2020·Obesity·Markos KalligerosEleftherios Mylonakis
May 1, 2020·Thrombosis Research·Corrado LodigianiUNKNOWN Humanitas COVID-19 Task Force
May 6, 2020·Critical Care : the Official Journal of the Critical Care Forum·Filipe S CardosoNuno Germano
May 6, 2020·Intensive Care Medicine·Julie HelmsUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sep
May 6, 2020·Journal of Thrombosis and Haemostasis : JTH·Saskia MiddeldorpNick van Es
May 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sean Wei Xiang OngDavid Chien Lye
May 24, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Jun WuXiangyou Li

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Citations

Nov 18, 2020·Journal of Medical Virology·Jun YangJiahao Li
Jan 3, 2021·Human Genomics·Ivan LaponogovKirill Veselkov
Dec 23, 2020·Epidemiology and Infection·Jiao YangYanChang Lei
Jan 20, 2021·Annals of the Academy of Medicine, Singapore·Jamie S Y HoChing Hui Sia
Nov 10, 2020·Endocrinología, Diabetes Y Nutrición·Miguel A Rubio Herrera, Irene Bretón Lesmes
Dec 10, 2020·Clinical and Translational Allergy·Jean BousquetUNKNOWN ARIA group
Mar 7, 2021·International Journal of Environmental Research and Public Health·Han Shi Jocelyn Chew, Violeta Lopez
Mar 14, 2021·Journal of Medical Virology·María Teresa ValenzuelaEugenio Ramírez
Apr 21, 2021·Obesity Medicine·Akibul Islam ChowdhurySompa Reza
May 7, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Arcelia Guerson-GilLawrence J Brandt
Nov 23, 2020·Journal of Sport and Health Science·Daniel WilsonNicholas Gill
Jun 1, 2021·Neuromuscular Disorders : NMD·Hagit LevineOded Scheuerman
Jun 5, 2021·Endocrinología, Diabetes Y Nutrición·Miguel A Rubio Herrera, Irene Bretón Lesmes
Jun 12, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Richard DanaOlivier Ziegler
Jul 7, 2021·Obesity Science & Practice·Sérgio BrasilLuiz Marcelo Sá Malbouisson
Jun 17, 2021·Arquivos brasileiros de cardiologia·Cléa Simone Sabino de Souza ColomboNabil Ghorayeb
Jul 15, 2021·Revista da Associação Médica Brasileira·Kathleen Cézar de MéloCarlos Dornels Freire de Souza
Jul 10, 2021·Ageing Research Reviews·Albin JohnP Hemachandra Reddy
May 1, 2021·Journal of Obesity & Metabolic Syndrome·Zeinab NikniazLeila Mokhtari
Aug 10, 2021·Current Oral Health Reports·Carina M Silva-Boghossian, Romulo S Dezonne
Aug 10, 2021·World Journal of Virology·Mahmoud NassarVincent Rizzo
May 12, 2021·Journal of Occupational and Environmental Medicine·Xavier Navarro-FontAlejandro Fernandez-Montero
Oct 14, 2021·Current Medical Research and Opinion·Andrew OsterlandPaul Godley

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Software Mentioned

Google Scholar
Clarivate Analytics
Comprehensive Meta ‐ Analysis
QUIPS
EndNote X9
PRISMA
Quality in Prognostic Studies ( QUIPS )

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