Obesity is a significant risk factor for prostate cancer at the time of biopsy.

Urology
Stephen J FreedlandWilliam J Aronson

Abstract

Studies suggest obesity is associated with decreased prostate cancer risk. We hypothesized obesity is biologically associated with increased risk, although this is obscured owing to hemodilution of prostate-specific antigen (PSA) and larger prostate size. We retrospectively studied 441 consecutive men undergoing prostate biopsy between 1999 and 2003 at two equal access centers within the Veterans Affairs Greater Los Angeles Healthcare System. We estimated the association between obesity (body mass index >or= 30 kg/m(2)) and positive biopsy and Gleason >or=4+3 using logistic regression analysis adjusting for multiple clinical characteristics. A total of 123 men (28%) were obese and 149 men (34%) had cancer. Median PSA and age were 5.7 ng/mL and 63.9 years, respectively. Obese men had significantly lower PSA concentrations (P = .02) and larger prostate volumes (P = .04). Obesity was not significantly related to age (P = .19) or race (P = .37). On univariate analysis, obesity was not associated with prostate cancer risk (odds ratio [OR] 1.13, 95% confidence interval [CI] 0.73-1.75, P = .58). However, after adjusting for multiple clinical characteristics, obesity was associated with significantly increased prostate cancer risk (OR ...Continue Reading

References

Aug 18, 1993·JAMA : the Journal of the American Medical Association·J E OesterlingM M Lieber
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Oct 13, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zhihong GongAlan R Kristal
Dec 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carmen RodriguezEugenia E Calle
Dec 21, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·David M WernyMark Wener
Nov 22, 2007·JAMA : the Journal of the American Medical Association·Lionel L BañezStephen J Freedland

❮ Previous
Next ❯

Citations

Nov 8, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Srinivas SamavediVipul R Patel
Sep 21, 2010·Nutrition Journal·Abdallah S Al-RethaiaaNaseem M Al-Shwaiyat
Dec 24, 2009·Prostate Cancer and Prostatic Diseases·I A Hekal, E I Ibrahiem
Jul 6, 2011·Prostate Cancer and Prostatic Diseases·D I ChuL L Bañez
Mar 16, 2013·Der Urologe. Ausg. A·B J Schmitz-DrägerUNKNOWN Mitglieder des Arbeitskreises Prävention, Umwelt und Komplementärmedizin (PUK) der Akademie der Deutschen Urologen
Feb 17, 2010·Cancer Causes & Control : CCC·Maria D JacksonRobert L Wan
Oct 12, 2013·Metabolism: Clinical and Experimental·Michael A TsoukasChristos S Mantzoros
Jan 19, 2010·Cancer Letters·Naghma KhanHasan Mukhtar
Jul 30, 2010·International Journal of Experimental Pathology·Andreia M RibeiroMariana P Monteiro
Apr 28, 2011·Cancer·David I Chu, Stephen J Freedland
Nov 29, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Hitoshi MasudaKazunori Kihara
Jul 23, 2011·BJU International·Umberto CapitanioFrancesco Montorsi
May 16, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Jae Heon KimSoon-Sun Kwon
Mar 15, 2011·Metabolism: Clinical and Experimental·Virginia KaklamaniBoris Pasche
Apr 14, 2015·Urologic Oncology·Alvin Lee, Sing Joo Chia
Oct 4, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C De NunzioA Tubaro
Jan 25, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Cosimo De NunzioAndrea Tubaro
Jan 24, 2018·Journal of Medical Radiation Sciences·Amy BrownAndrew Fielding
Feb 21, 2018·BJU International·Zeyad D NassarLisa M Butler
May 18, 2012·Endocrine-related Cancer·Dara Hope Cohen, Derek LeRoith
Feb 10, 2009·Nature Clinical Practice. Urology·Amit R Patel, Eric A Klein
Aug 4, 2011·Nature Reviews. Urology·Jan Hammarsten, Ralph Peeker
Nov 5, 2013·Occupational and Environmental Medicine·Judith M GraberMichael D Attfield
Nov 20, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Limin YueWeidong Zhang
Sep 8, 2017·The World Journal of Men's Health·Deok Ha SeoJae Seog Hyun
Oct 31, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi Oike, Mitsuhisa Tabata
Apr 24, 2018·International Journal of Dentistry·Shahida MaqsoodMuznah Khalid
May 4, 2021·Critical Reviews in Food Science and Nutrition·Giovanna MuscogiuriAntongiulio Faggiano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.