Obesity Is Associated With Gene Expression and Imaging Markers of Iron Accumulation in Skeletal Muscle

The Journal of Clinical Endocrinology and Metabolism
José M Moreno-NavarreteJosé M Fernández-Real

Abstract

Different genetic and imaging iron markers are known to be increased in the liver, adipose tissue, and brain of obese subjects. We aimed to investigate these markers in human skeletal muscle. DESIGN, SETTING, PATIENTS, AND OUTCOME MEASURES: Markers of iron accumulation were measured in three different territories: Iron gene markers (TFRC1, TF, SLC11A2, FTL, FTH1, and SLC40A1) were studied in abdominal rectus abdominis (Cohort 1, n = 26) and quadriceps (Cohort 2, n = 13) muscle using real-time PCR, whereas paravertebral muscle R2* signal (as surrogate of iron content) (Cohort 3, n = 43) was evaluated by means of magnetic resonance imaging. In a subgroup of 14 obese participants from Cohort 3, a diet-induced weight loss was performed. Rectus abdominis muscle age-adjusted gene expression of SLC40A1 (ferroportin) (r = 0.47; P = .04), SLC11A2 (r = 0.50; P = .03) and CYBA (r = 0.62; P = .006) increased with body fatness. In obese participants from Cohort 1, muscle CYBA gene expression was positively correlated with serum ferritin. This association was replicated in quadriceps from obese participants (Cohort 2). Paravertebral muscle R2* was positively associated with body mass index, waist circumference, and fat mass (measured by dual...Continue Reading

Associated Clinical Trials

Mar 26, 2019·José Manuel Fernández-Real

Citations

Nov 21, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R-H HaoY Guo
Mar 15, 2018·Molecular Nutrition & Food Research·Silvia Barja-FernandezRubén Nogueiras
Oct 3, 2018·International Journal of Environmental Research and Public Health·Joanna GajewskaMagdalena Chełchowska
Jul 25, 2019·PloS One·Danielle M FitzgeraldMelody A de Laat
Jul 15, 2017·Scientific Reports·José María Moreno-NavarreteJosé Manuel Fernández-Real
Jun 23, 2020·Journal of Nutrition and Metabolism·Elena V TchetinaEugeniya P Sharapova
May 11, 2018·International Journal of Chronic Diseases·Axel DignassJürgen Stein
Feb 10, 2021·Experimental Physiology·Benjamin J RyanJeffrey F Horowitz

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