Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy.

Annals of Indian Academy of Neurology
Mythili AyyagariVenkateswarlu Kolachana

Abstract

Women with epilepsy (WWE) have an increased risk for several endocrine disorders. Obesity and Polycystic Ovarian Syndrome (PCOS) are common side-effects of anticonvulsant drugs. To study the prevalence of Obesity, PCOS, Thyroid dysfunction in WWE on monotherapy with Carbamazepine (CBZ), Sodium Valproate (VAL) and Phenytoin (DPH) MATERIAL AND METHODS: Sixty WWE in the reproductive age group (13 - 45 yr) who are on atleast 6 months of monotherapy with either CBZ (20) or VAL (20) or DPH (20) are subjects of the study. Their Anthropometric data is recorded. They are interviewed and investigated for PCOS and thyroid dysfunction. Twenty healthy women in the reproductive age group served as controls. BMI>25 is taken as cut-off for Obesity. PCOS is defined as menstrual irregularity and/or clinical /biochemical hyperandrogenism with ultrasound evidence of PCO as per the Rotterdam criteria. TSH <0.1 and >4 is taken as evidence of thyroid dysfunction. Women are grouped according to the anticonvulsant drug received and the data analyzed in each group. The mean BMI among VAL and CBZ users is significantly higher than among DPH users (23.3 & 23.4 vs 20.4). There is no significant difference in incidence of PCOS among WWE using either DPH or...Continue Reading

References

Nov 4, 1993·The New England Journal of Medicine·J I IsojärviV V Myllylä
May 1, 1996·Annals of Neurology·J I IsojärviV V Myllylä
Apr 18, 1998·Annals of Neurology·J I IsojärviJ S Tapanainen
Jan 23, 1999·Epilepsia·C S Woolley, P A Schwartzkroin
Nov 24, 1999·Frontiers in Neuroendocrinology·F F Casanueva, C Dieguez
Mar 10, 2001·Cell·B M Spiegelman, J S Flier
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·H JoffeJ E Hall
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·L BiloC Nappi
Aug 3, 2001·Pediatric Neurology·A VerrottiF Chiarelli
May 25, 2002·Epilepsia·Virpi PylvänenJouko I T Isojärvi
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jan 13, 2004·Human Reproduction Update·Adam H BalenDidier Dewailly
Feb 26, 2005·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Philip LoweDonna Howlett
Sep 16, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·F J BroekmansB C J M Fauser
Mar 1, 2007·Epilepsia·Liat de VriesHadassa Goldberg-Stern
Oct 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Bulent O YildizRicardo Azziz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.