Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga(+/-) mice

Diabetologia
Yong Ryoul YangPann-Ghill Suh

Abstract

O-GlcNAcylation plays a role as a metabolic sensor regulating cellular signalling, transcription and metabolism. Transcription factors and signalling pathways related to metabolism are modulated by N-acetyl-glucosamine (O-GlcNAc) modification. Aberrant regulation of O-GlcNAcylation is closely linked to insulin resistance, type 2 diabetes and obesity. Current evidence shows that increased O-GlcNAcylation negatively regulates insulin signalling, which is associated with insulin resistance and type 2 diabetes. Here, we aimed to evaluate the effects of Oga (also known as Mgea5) haploinsufficiency, which causes hyper-O-GlcNAcylation, on metabolism. We examined whether Oga(+/-) mice developed insulin resistance. Metabolic variables were determined including body weight, glucose and insulin tolerance, metabolic rate and thermogenesis. Oga deficiency does not affect insulin signalling even at hyper-O-GlcNAc levels. Oga(+/-) mice are lean with reduced fat mass and improved glucose tolerance. Furthermore, Oga(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism. Oga haploinsufficiency potentiates energy expenditure through the enhancement of brown adipocyte differentiation from...Continue Reading

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Citations

Apr 14, 2016·Stem Cells International·Miroslava CedikovaJitka Kuncova
Mar 15, 2016·Scientific Reports·Michael C RyczkoJames W Dennis
Apr 4, 2017·Scientific Reports·Yong Ryoul YangPann-Ghill Suh
May 11, 2017·Nature Reviews. Molecular Cell Biology·Xiaoyong Yang, Kevin Qian
Jan 19, 2018·Journal of Bioenergetics and Biomembranes·Zachary A BacigalupaMauricio J Reginato
May 24, 2018·Journal of Bioenergetics and Biomembranes·Olof Lagerlöf
Jul 31, 2020·Physiological Reviews·John C ChathamAdam R Wende
Apr 19, 2021·Current Diabetes Reports·Simona CataldiMarianna Aprile

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