Obesity: the hormonal milieu

Current Opinion in Endocrinology, Diabetes, and Obesity
Anne Lenz, Frank B Diamond

Abstract

Obesity has reached epidemic proportions throughout the world and poses significant health and economic burdens to both developed and developing societies. Most recent data from the NHANES study (2003-2004) report that 17.1% of US children are overweight and 32.2% of adults are obese, a significant increase compared with data obtained only 6 years earlier. The neurohormonal control of appetite, body composition, and glucose homeostasis is mediated by hormones secreted from adipose tissue, endocrine glands, and enteroendocrine cells, which converge at the vagus nerve, brainstem and hypothalamus to modulate complex interactions of neurotransmitters and central appetite-regulating peptides. These hormonal signals are tightly regulated to maintain body weight/adiposity within a narrow, individually defined range that may be further impacted by variables such as ingested calories, meal composition, and lifestyle. Clinical manifestations of obesity, the metabolic syndrome and impaired glucose tolerance reflect biochemical alterations in a complex hormonal milieu. Elucidation of these hormonal perturbations in obese patients has already provided novel pharmacologic treatments to improve weight management and address the metabolic sequ...Continue Reading

References

Oct 1, 1995·The American Journal of Clinical Nutrition·D E LarsonE Ravussin
Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
Feb 10, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·D F Hopkins, G Williams
Nov 5, 1999·JAMA : the Journal of the American Medical Association·S B HeymsfieldM McCamish
Jan 8, 2000·Acta Paediatrica. Supplement·K K OngD B Dunger
Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·L Ste MarieR D Palmiter
Apr 6, 2001·Diabetes·M TschöpM L Heiman
Jul 31, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C VerdichA Astrup
Aug 2, 2001·Nature Medicine·A R Saltiel
Jun 18, 2002·Nature Medicine·Norikazu MaedaYuji Matsuzawa
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·William A BanksMark L Heiman
Aug 2, 2002·Biochemical and Biophysical Research Communications·T SuginoY Terashima
Aug 9, 2002·Nature·Rachel L BatterhamStephen R Bloom
Nov 12, 2002·Nature Medicine·Silvana ObiciLuciano Rossetti
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Angelo DelParigiP Antonio Tataranni
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Daniel E FlanaganRobert S Sherwin
Mar 1, 2003·Frontiers in Neuroendocrinology·Kevin D Niswender, Michael W Schwartz
Apr 11, 2003·Neuroscience Letters·Thomas RiedigerErwin Scharrer
Apr 11, 2003·Regulatory Peptides·Philippe SamamaJoseph F Grippo
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Jul 31, 2003·European Journal of Endocrinology·Donatella CortelazziAnna Spada
Sep 5, 2003·The New England Journal of Medicine·Rachel L BatterhamStephen R Bloom

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Citations

Aug 7, 2008·International Journal of Clinical Practice·H E BaysUNKNOWN Adiposopathy Working Group
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Patricio López-JaramilloStefany Triana-Cubillos
Dec 22, 2009·Holistic Nursing Practice·Lauren Outland
Dec 3, 2015·Current Obesity Reports·Solange S Pereira, Jacqueline I Alvarez-Leite
Jul 18, 2018·International Journal of Molecular Sciences·Nahum Mendez-SanchezJaqueline Cordova-Gallardo
Nov 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tahereh FarkhondehSaeed Samarghandian
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Manal MansourHeba A El Malt
Oct 21, 2021·Biology of Reproduction·Verônyca Gonçalves PaulaGustavo Tadeu Volpato

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