Obestatin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats

Oxidative Medicine and Cellular Longevity
Aleksandra MatuszykA Dembiński

Abstract

Obestatin, a 23-amino acid peptide derived from the proghrelin, has been shown to exhibit some protective and therapeutic effects in the gut. The aim of present study was to determine the effect of obestatin administration on the course of acetic acid-induced colitis in rats. Materials and Methods. Studies have been performed on male Wistar rats. Colitis was induced by a rectal enema with 3.5% acetic acid solution. Obestatin was administered intraperitoneally twice a day at a dose of 8 nmol/kg, starting 24 h after the induction of colitis. Seven or 14 days after the induction of colitis, the healing rate of the colon was evaluated. Results. Treatment with obestatin after induction of colitis accelerated the healing of colonic wall damage and this effect was associated with a decrease in the colitis-evoked increase in mucosal activity of myeloperoxidase and content of interleukin-1β. Moreover, obestatin administration significantly reversed the colitis-evoked decrease in mucosal blood flow and DNA synthesis. Conclusion. Administration of exogenous obestatin exhibits therapeutic effects in the course of acetic acid-induced colitis and this effect is related, at least in part, to the obestatin-evoked anti-inflammatory effect, an i...Continue Reading

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Citations

Jul 20, 2016·Gastroenterology Research and Practice·Artur DembińskiPeter Christopher Konturek
Sep 7, 2016·International Journal of Molecular Sciences·Aleksandra MatuszykArtur Dembiński
Jun 12, 2018·Pharmaceutical Development and Technology·Trusha J PurohitZimei Wu
Jun 11, 2020·International Journal of Molecular Sciences·Nikoletta AlmásiKrisztina Kupai
Oct 18, 2018·International Journal of Environmental Research and Public Health·Karolina Skonieczna-ŻydeckaWojciech Marlicz
May 26, 2017·International Journal of Molecular Sciences·Piotr CeranowiczArtur Dembiński
Apr 3, 2019·International Journal of Molecular Sciences·Agnieszka StempniewiczZygmunt Warzecha
Sep 21, 2019·European Journal of Pharmacology·Carlos Eduardo S MonteiroPedro Marcos Gomes Soares
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed A MorsyYasmine F Ibrahim
Sep 19, 2021·Pharmacological Reports : PR·Hubert ZatorskiJakub Fichna

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