Obestatin controls skeletal muscle fiber-type determination

Scientific Reports
Icía Santos-ZasJesús P Camiña

Abstract

Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile properties and metabolic profile of skeletal muscle through determination of oxidative fiber type. Our data indicate that obestatin regulates Mef2 activity and PGC-1α expression. Both mechanisms result in a shift in muscle metabolism and function. The increase in Mef2 and PGC-1α signaling activates oxidative capacity, whereas Akt/mTOR signaling positively regulates myofiber growth. Taken together, these data indicate that the obestatin signaling acts on muscle fiber-type program in skeletal muscle.

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Citations

Oct 1, 2019·Anatomia, histologia, embryologia·Hakan SağsözBerna Güney Saruhan
Sep 15, 2018·Journal of Cachexia, Sarcopenia and Muscle·Jessica González-SánchezJesús P Camiña
Jan 6, 2021·Cellular and Molecular Neurobiology·Agustín Sánchez-TempranoYolanda Pazos
May 15, 2021·Developmental Medicine and Child Neurology·Karyn G RobinsonRobert E Akins
Nov 10, 2018·Life Sciences·Thaynan Raquel Dos Prazeres OliveiraRaquel da Silva Aragão

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Methods Mentioned

BETA
coimmunoprecipitation
force measurements
biopsy

Software Mentioned

ImageJ64

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