Object exploration in the developing rat: methodological considerations

Developmental Psychobiology
C J Heyser, Jennifer S Ferris

Abstract

The current study was conducted to characterize the ontogeny of novel object recognition in rats. Initial testing (Experiment 1) was conducted in a square arena and it was observed that 21-day-old animals would often pause in the corners, greatly increasing between-subject variability and performance in this test. Significantly greater object exploration and less variability were obtained using a circular arena. In Experiment 2, we report object exploration in 21, 35, 42, and 90-day-old male and female Sprague-Dawley rats using a circular arena. The results show that measures of locomotor activity, object exploration, and within session habituation of these behaviors were surprisingly similar across all ages. Gender differences in locomotor activity were not observed until 42 days of age. Reliable recognition memory was observed at all ages. It is concluded that the novel object recognition test appears well suited for use in young rats.

References

Jul 1, 1992·Physiological Reviews·B M SpruijtW H Gispen
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Oct 1, 1966·Journal of Comparative and Physiological Psychology·D E BerlyneT Hirota
May 1, 1995·Physiology & Behavior·A M van ErpM J Nijsen
May 1, 1996·Behavioural Brain Research·M T BardoN G Harrington
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Jan 26, 2002·Behavioural Brain Research·Bret A MorrowRobert H Roth
Feb 8, 2003·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·Faisal Mohammed Salih BasamaAmanda Price
Jun 12, 2003·Behavioural Brain Research·David Eilam
May 25, 2004·Psychological Reports·Matthew J AndersonDavid C Riccio
Jun 16, 2004·Behavioural Brain Research·Susan B PowellMartin P Paulus
Jul 15, 2004·Annals of the New York Academy of Sciences·Charles J HeyserJennifer S Ferris
Oct 27, 2004·Behavioural Processes·Joanna Komorowska, Sergio M Pellis
Feb 25, 2005·Behavioral Neuroscience·Inah LeeRaymond P Kesner
Feb 9, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Junran CaoFrances M Leslie
Mar 21, 2007·Neuroscience and Biobehavioral Reviews·Ekrem DereMaria A De Souza Silva
Aug 28, 2007·Journal of Neuroscience Methods·Janelle M SilversRosemarie M Booze
Dec 21, 2007·Behavioural Brain Research·Ling-Ling WuZheng-Yan Zhao
May 24, 2008·Neuroscience and Biobehavioral Reviews·Boyer D WintersTimothy J Bussey
Sep 16, 2008·Pharmacology, Biochemistry, and Behavior·Eluza Curte StangherlinCristina Wayne Nogueira
Sep 10, 2009·Developmental Psychobiology·Maxine L RegerChristopher C Giza
Apr 2, 2011·Developmental Psychobiology·De-Laine M Cyrenne, Gillian R Brown
Dec 21, 2011·Behavioural Processes·Charles J Heyser, Anthony Chemero
Dec 1, 1997·Behavioural Processes·R N Hughes
Jan 1, 1992·Behavioural Processes·C Thinus-BlancB Poucet

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Citations

Aug 13, 2013·Behavioural Brain Research·S A JablonskiM E Stanton
Jul 16, 2019·Nutritional Neuroscience·Hayarelis Moreno, Isabel de Brugada
Dec 27, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Abigail SpeightJörg-Peter W Voigt
Jul 2, 2020·Scientific Reports·Arely Cruz-SanchezMaithe Arruda-Carvalho
Dec 12, 2020·Neurobiology of Learning and Memory·Arely Cruz-SanchezMaithe Arruda-Carvalho

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