Objective assessment of bradykinesia in Parkinson's disease using evolutionary algorithms: clinical validation

Translational Neurodegeneration
Chao GaoShengdi Chen

Abstract

There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping (FT) that uses evolutionary algorithms (EAs) and explore whether it can be used to identify early stage Parkinson's disease (PD). One hundred and seven PD, 41 essential tremor (ET) patients and 49 normal controls (NC) were recruited. Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger. Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs. The output from the device (referred to as "PD-Monitor") scaled from - 1 to + 1 (where higher scores indicate greater severity of bradykinesia). Meanwhile, the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) FT item. With an increasing MDS-UPDRS FT score, the PD-Monitor score from the same hand side increased correspondingly. PD-Monitor score correlated well with MDS-UPDRS FT score (right side: r = 0.819, P = 0.000; lef...Continue Reading

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Citations

Oct 28, 2019·Nursing·Vincent M Vacca
Mar 13, 2020·Sleep·Félix Javier Jiménez-JiménezJosé A G Agúndez
Aug 7, 2019·Translational Neurodegeneration·Gen LiShengdi Chen
Apr 22, 2020·Journal of Neuroengineering and Rehabilitation·Nicholas ShawenArun Jayaraman
Jul 3, 2020·Translational Neurodegeneration·Ning-Ning Che, Hong-Qi Yang
Aug 30, 2020·Disease Models & Mechanisms·Gideon L HughesMary Elizabeth Pownall
Mar 24, 2021·Current Neurology and Neuroscience Reports·Félix Javier Jiménez-JiménezJosé A G Agúndez
Jun 3, 2021·Pharmaceuticals·Félix Javier Jiménez-JiménezJosé A G Agúndez

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Methods Mentioned

BETA
MDS

Software Mentioned

SPSS
Monitor
PD

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