Objective assessment of flap volume changes and aesthetic results after adjuvant radiation therapy in patients undergoing immediate autologous breast reconstruction

PloS One
Yujin MyungJae Hoon Jeong

Abstract

The use of immediate breast reconstruction and adjuvant radiation therapy is increasing in breast cancer patients. This study aimed to analyze the aesthetic outcome and changes in flap volume in patients with breast cancer undergoing radiation therapy of the surgical site after immediate autologous tissue reconstruction. Immediate abdominal free flap breast reconstruction following unilateral mastectomy was performed in 42 patients; 21 patients received adjuvant radiation (study group) and 21 patients did not (control group). To compare flap volume, three-dimensional computed tomography (CT) was performed before and after radiation. Also, aesthetic analysis was performed in both groups to evaluate shape changes. There was a 12.3% flap volume reduction after the completion of radiation in the experimental group that was significantly greater than the 2.6% volume reduction observed in the non-radiation group (P<0.01). There was no significant difference in the short- and long-term aesthetic results between the groups. When performing immediate autologous breast reconstruction, 14% volume overcorrection is recommended for patients in whom adjuvant radiation therapy is anticipated to improve aesthetic outcomes.

References

Jun 25, 2004·Clinical Oncology : a Journal of the Royal College of Radiologists·I S SoongA W M Lee
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Penny R AndersonGary M Freedman
Jul 4, 2007·The Breast : Official Journal of the European Society of Mastology·Maria João CardosoConny Vrieling
Nov 21, 2007·The Breast : Official Journal of the European Society of Mastology·Veronique GuyomardMark Wilkinson
May 13, 2008·International Journal of Radiation Oncology, Biology, Physics·Jigna Desai JhaveriJay L Bosworth
Dec 27, 2008·The Breast : Official Journal of the European Society of Mastology·Alexandre Mendonça MunhozMarcus C Ferreira
Mar 8, 2012·World Journal of Surgery·Jean-Yves PetitKrishna B Clough
Jun 27, 2013·La Radiologia medica·Alessia CarnevaleRiccardo Maurizi Enrici
Jul 27, 2014·International Journal of Surgery·Mirela ErićMiodrag Drapšin
May 4, 2015·The Breast : Official Journal of the European Society of Mastology·Rachel L O'ConnellJennifer E Rusby
Jul 2, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tosol YuIn Ah Kim
Jun 12, 2016·The Breast : Official Journal of the European Society of Mastology·S B ChoppinA Goyal
May 26, 2017·Plastic and Reconstructive Surgery·Horatiu MuresanDaniel J Ceradini
Dec 6, 2017·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Kathryn H SteeleStephen J McCulley

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Citations

Sep 22, 2020·Journal of Reconstructive Microsurgery·Adee J HeimanJoseph A Ricci
Jan 12, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Korri S HershenhouseKetan M Patel
Apr 20, 2021·Plastic and Reconstructive Surgery. Global Open·Chang Min KangSang Gyu Kwak
Jul 4, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Yu KagayaSatoshi Akazawa

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