Objective assessment of nonadherence and unknown co-medication in hospitalized patients.

European Journal of Clinical Pharmacology
Florentine CarowWalter E Haefeli

Abstract

The intake of medications (drugs) without the knowledge of the treating physician (unknown co-medication) and nonadherence strongly influence drug safety. The aim of our study was to objectively assess unknown co-medication and nonadherence in hospitalized patients by screening urine for a large number of drugs using highly sensitive full scan gas chromatograpy/mass spectrometry (GC/MS). Secondary objectives were to determine the relationship of co-medication and nonadherence to the number of drugs prescribed and to compare history-taking by a pharmacist versus a physician. In 152 patients, the drug histories taken by physicians, patients' self-reported adherence, and information compiled during as many as three structured interviews conducted by a trained pharmacist on days 1-2, 3-4, and 7-11 of the hospital stay were compared with the GC/MS results from urine samples collected after each interview. In the interviews performed by the pharmacist, 235 additional drugs were identified that were not documented in the chart. Of all the drugs indicated in any interview, 16.9% were identified only by the physician, 24.1% only by the pharmacist, and 59% by both. Overall, in 78% of the patients at least one additional drug was identifi...Continue Reading

References

Jul 1, 1972·Clinical Pharmacology and Therapeutics·R B Stewart, L E Cluff
Jan 1, 1981·European Journal of Clinical Pharmacology·U Bergman, B E Wiholm
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·I JohanssonM Ingelman-Sundberg
May 1, 1996·Journal of Accident & Emergency Medicine·I AkwagyriamH Millington
Jul 8, 1998·Lancet·D Schmassmann-SuhijarW E Haefeli
Jun 26, 1999·Lancet·M SchwabK Mörike
Jul 18, 2001·Internal Medicine Journal·M ChanJ H Vial
Jun 16, 2004·European Journal of Clinical Pharmacology·Karin RiegerMeret Martin-Facklam
Sep 18, 2004·British Journal of Clinical Pharmacology·Meret Martin-FacklamWalter E Haefeli
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Vincent C TamEdward E Etchells
Jan 19, 2006·Advances in Therapy·Kem P KruegerBill Felkey
Aug 26, 2006·Drugs & Aging·Robert M KaiserJoseph T Hanlon
Dec 13, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Melinda K CarterDennis Grauer
Sep 6, 2007·European Journal of Clinical Pharmacology·H M SeidlingW E Haefeli
Sep 18, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kristina Johnell, Inga Klarin
Sep 13, 2008·Pharmacy World & Science : PWS·Thilo BertscheWalter E Haefeli
Apr 30, 2010·Quality & Safety in Health Care·H M SeidlingW E Haefeli
May 7, 2010·Pharmacy World & Science : PWS·Louise Lindved KarkovLotte S Haugbølle
May 27, 2010·Nursing in Critical Care·Siobhan WarneNicola Donlin
Aug 20, 2010·Quality & Safety in Health Care·Richard C NewtonStuart Whittaker
Aug 24, 2010·European Heart Journal·Ulrich LaufsMichael Böhm

❮ Previous
Next ❯

Citations

Aug 30, 2014·Expert Opinion on Drug Safety·Christian LeporiniEmilio Russo
Jun 25, 2015·European Journal of Clinical Pharmacology·Julia FreigofasWalter Emil Haefeli
Jun 17, 2016·European Journal of Clinical Pharmacology·Lea BotermannMartin Schulz
Jul 20, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Ute BlassmannTorsten Hoppe-Tichy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Pharmacology
Karin RiegerMeret Martin-Facklam
Journal of Pediatric Gastroenterology and Nutrition
Maria M Oliva-HemkerRichard E Thompson
© 2022 Meta ULC. All rights reserved