Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy

World Journal of Gastroenterology : WJG
Masato AiHiromitsu Saisho

Abstract

To objectively evaluate the effect of TJ-68 on colonic spasms during colonoscopy. One hundred and one patients subjected to screening colonoscopy were randomly assigned to two groups: TJ-68 in 51 subjects and saline as the control in 50. The endoscope was inserted into the sigmoid colon, then a spastic region was identified and the tip of the colonoscope was positioned at a distance of about 10 mm from the spastic region. The endoscopic view was recorded before and after direct spraying of the TJ-68 solution or warm saline. The intraluminal area of the spastic region was serially measured using a computer image analyzer and expressed as pixel counts. The area under the curve (AUC) was calculated from the pixel curve. Statistical significance was assessed by Wilcoxon's test and Mann-Whitney U test. The mean AUC of the spastic region before and after TJ-68 spraying was 29,128 and 121,943 pixels, respectively, while with saline, it was 31,635 pixels and 48,617 pixels, respectively. Thus, the AUC significantly increased after TJ-68 spraying compared with the spraying of saline (P<0.001). Direct spraying of TJ-68 on the colonic mucosa suppressed colonic spasm and it may be useful during colonoscopy when anticholinergic agents are co...Continue Reading

References

Oct 1, 1995·Gastrointestinal Endoscopy·C S CutlerG A Lehman
Mar 1, 1996·Gastrointestinal Endoscopy·B P Saunders, C B Williams
May 27, 1999·Gastrointestinal Endoscopy·J B MarshallB Banerjee

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Citations

Aug 7, 2010·Journal of the Chinese Medical Association : JCMA·Maw-Shiou JongFang-Pey Chen
Jun 17, 2014·World Journal of Gastrointestinal Endoscopy·Lucio TrevisaniSergio Sartori
May 10, 2012·The Journal of Obstetrics and Gynaecology Research·Shoko TsujiHideharu Kanzaki
Nov 26, 2014·The Journal of Obstetrics and Gynaecology Research·Genichiro SumiHideharu Kanzaki
Nov 6, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Dongwook KwakChangsu Na
Jun 4, 2020·Journal of General and Family Medicine·Koshi OtaAkira Takasu

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