Objective evaluation for treat to target in Crohn's disease.

Journal of Gastroenterology
Kento TakenakaKazuo Ohtsuka

Abstract

Crohn's disease (CD) is a chronic and destructive bowel disease; continued disease activity can lead to penetrating complications. With the recent advent of effective medications, the importance of using a treat-to-target approach to guide therapy is becoming important. In this review, we reviewed the previous evidence for evaluating CD lesions. We describe ileocolonoscopy's role in assessing disease activity, as well as recent progress in modalities, such as balloon-assisted endoscopy, capsule endoscopy, magnetic resonance enterography, computed tomography enterography, and ultrasonography. Advances in modalities have changed CD assessment, with small-bowel involvement becoming more important. Proper optimization is necessary in clinical practice.

References

Oct 1, 1990·Gastroenterology·P RutgeertsM Hiele
Jun 6, 2000·Nature·G IddanP Swain
Mar 23, 2002·Gastroenterology·David A SchwartzWilliam J Sandborn
Oct 9, 2004·Inflammatory Bowel Diseases·Séverine VermeirePaul Rutgeerts
Nov 20, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hironori YamamotoKentaro Sugano
May 12, 2005·Gastroenterology·Laurence MaidenIngvar Bjarnason
Jul 20, 2006·The American Journal of Gastroenterology·Adam S CheifetzBlair S Lewis
Jan 2, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C M GirelliF Rocca
Aug 8, 2007·Gastroenterology·Kathrine Frey FrøslieUNKNOWN IBSEN Group
Oct 3, 2007·Gastrointestinal Endoscopy·Akira FukumotoKentaro Sugano
Oct 2, 2007·Alimentary Pharmacology & Therapeutics·C HassanS Morini
Sep 19, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jennifer JonesWilliam J Sandborn
Jul 9, 2009·The American Journal of Gastroenterology·Melissa TukeyAlan C Moss
Oct 13, 2009·Gastroenterology·Filip BaertUNKNOWN North-Holland Gut Club
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
May 3, 2011·Gastroenterology·Jacques CosnesAntoine Cortot
May 31, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David H BruiningJoel G Fletcher
Apr 17, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sunil SamuelWilliam J Sandborn
Jul 31, 2012·Gut·Markus F Neurath, Simon P L Travis
Apr 16, 2013·Gastroenterology·Siew C NgUNKNOWN Asia–Pacific Crohn's and Colitis Epidemiologic Study (ACCESS) Study Group
Sep 14, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A MenysS A Taylor
Oct 1, 2013·International Journal of Clinical Practice·S ChatuR C G Pollok
Nov 20, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Guillaume BouguenWilliam J Sandborn

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Citations

Apr 26, 2020·International Journal of Molecular Sciences·Antonelly Cassio Alves de CarvalhoSandra M Barbalho
Jun 15, 2021·Internal Medicine·Masanao NakamuraMitsuhiro Fujishiro
Jul 23, 2021·Digestive Diseases and Sciences·Vítor Macedo SilvaJosé Cotter

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BETA
surgical resection
imaging technique

Software Mentioned

MaRIA

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