Objective response rate assessment in oncology: Current situation and future expectations

World Journal of Clinical Oncology
Nuri Faruk Aykan, Tahsin Özatlı

Abstract

The tumor objective response rate (ORR) is an important parameter to demonstrate the efficacy of a treatment in oncology. The ORR is valuable for clinical decision making in routine practice and a significant end-point for reporting the results of clinical trials. World Health Organization and Response Evaluation Criteria in Solid Tumors (RECIST) are anatomic response criteria developed mainly for cytotoxic chemotherapy. These criteria are based on the visual assessment of tumor size in morphological images provided by computed tomography (CT) or magnetic resonance imaging. Anatomic response criteria may not be optimal for biologic agents, some disease sites, and some regional therapies. Consequently, modifications of RECIST, Choi criteria and Morphologic response criteria were developed based on the concept of the evaluation of viable tumors. Despite its limitations, RECIST v1.1 is validated in prospective studies, is widely accepted by regulatory agencies and has recently shown good performance for targeted cancer agents. Finally, some alternatives of RECIST were developed as immune-specific response criteria for checkpoint inhibitors. Immune RECIST criteria are based essentially on defining true progressive disease after a c...Continue Reading

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Citations

Jun 15, 2020·Clinical Pharmacology and Therapeutics·Nicholas J SchorkJeffrey Trent
Jul 30, 2020·Medicina·Maria Isabella DoneganiSilvia Morbelli
Jan 13, 2021·Cancers·Faruque Azam, Alexei Vazquez
Feb 10, 2021·Journal for Immunotherapy of Cancer·Thomas KelleherDominic F Labriola
Aug 28, 2021·Biomedicines·Daniel-Clement Osei-BordomNiki Christou

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Methods Mentioned

BETA
biopsy
imaging techniques
MDA
X-ray

Software Mentioned

imRECIST
iRECIST
mRECIST
iPERCIST
irRECIST
PERCIST
EASL
qEASL
irRC
RECIST

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