Objectively Diagnosed Diffuse White Matter Abnormality at Term Is an Independent Predictor of Cognitive and Language Outcomes in Infants Born Very Preterm.

The Journal of Pediatrics
Nehal A ParikhKeith O Yeates

Abstract

To externally validate the independent value of objectively diagnosed diffuse white matter abnormality (DWMA; also known as diffuse excessive high signal intensity) volume to predict neurodevelopmental outcomes in very preterm infants (≤31 weeks of gestational age). A prospective, multicenter, regional population-based cohort study in 98 very preterm infants without severe brain injury on magnetic resonance imaging (MRI). DWMA volume was diagnosed objectively on structural MRI at term-equivalent age using our published algorithm. Multivariable linear regression was used to assess the value of DWMA volume to predict cognitive and language scores on the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) at 2 years corrected age. Of the infants who returned for follow-up (n = 74), the mean (SD) gestational age was 28.2 (2.4) weeks, and 42 (56.8%) were boys. In bivariable analyses, DWMA volume was a significant predictor of Bayley-III cognitive and language scores. In multivariable analyses, controlling for known predictors of Bayley-III scores (ie, socioeconomic status, gestational age, sex, and global brain abnormality score), DWMA volume remained a significant predictor of cognitive (P < .001) and langua...Continue Reading

Citations

Jan 11, 2021·The Journal of Pediatrics·T Michael O'SheaLex W Doyle
Nov 15, 2020·Diagnostic and Interventional Imaging·Baptiste MorelUNKNOWN EPIRMEX study group
Dec 2, 2020·The Journal of Pediatrics·Nehal A ParikhUNKNOWN Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators

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