PMID: 9421458Jan 8, 1998Paper

Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attempt

Journal of Neurotrauma
S FalciA Seiger

Abstract

Cystic lesions of the spinal cord (syringomyelia) may occur after spinal cord injury. Posttraumatic syringomyelia may result in a myelopathy causing symptoms of sensory and motor loss, as well as worsening spasticity, pain, hyperhidrosis, and autonomic dysreflexia. Shunting of the cyst cavity along with untethering of the scarred spinal cord is widely accepted as the treatment of choice. However, the long-term stabilization of the progressive myelopathy caused by a posttraumatic cyst is suboptimal because of arachnoidal rescarring, shunt tube blockage, and cyst reexpansion. A new neurosurgical strategy to overcome the complication of cyst reexpansion was designed. Experimental studies have shown the successful use of embryonic spinal cord grafts, including human grafts, to obliterate induced spinal cord cavities in rats. The authors report the first use of solid human embryonic spinal cord grafts to successfully obliterate 6 cm of a large cyst cavity in a patient becoming myelopathic from a posttraumatic cyst. The grafts are well visualized by MRI to the 7-month postoperative follow-up and cyst obliteration is seen in the region where the grafts were placed.

References

Jan 1, 1990·Experimental Brain Research·E Kunkel-Bagden, B S Bregman
Mar 22, 1988·The Journal of Comparative Neurology·J D Houlé, P J Reier
Jan 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K H Jones, J A Senft
May 15, 1986·The Journal of Comparative Neurology·P J ReierJ R Wujek
Nov 1, 1986·Transplantation·O Ringdén
Feb 1, 1986·The Journal of Comparative Neurology·B S Bregman, P J Reier
Jan 1, 1994·British Journal of Neurosurgery·R Edgar, P Quail
Sep 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·M V Squier, R P Lehr
Aug 1, 1996·Journal of Neurosurgery·S Sgouros, B Williams

❮ Previous
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Citations

Jan 29, 2000·Brain Research. Developmental Brain Research·E AkessonE Sundström
Oct 10, 2002·Brain Research Bulletin·Gerard J Boer, Håkan Widner
Sep 2, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Peter E Batchelor, David W Howells
Sep 22, 2001·Journal of Neurotrauma·E D WirthD K Anderson
Feb 24, 2001·Journal of Neurotrauma·C E HulseboschW Young
Jan 3, 2006·Journal of Neurologic Physical Therapy : JNPT·Maria J Amador, James D Guest
Jun 13, 2003·The Neurologist·Daniel BeckerJohn W McDonald
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Paul J Reier
May 17, 2008·Upsala Journal of Medical Sciences·Leif AnderbergAnders Holtz
Nov 26, 2009·Journal of Neurosurgery. Spine·Scott P FalciDaniel P Lammertse
May 9, 2006·Neurosurgical Focus·U Batzdorf
May 9, 2006·Neurosurgical Focus·L T HollyU Batzdorf
Mar 2, 2006·Journal of Neurosurgery. Spine·Adrian W Laxton, Richard G Perrin
Feb 15, 2002·Lancet·John W McDonald, Cristina Sadowsky
Jul 10, 2003·Lancet Neurology·Michael E Selzer
Sep 23, 2003·American Journal of Physical Medicine & Rehabilitation·John W McDonald, Daniel Becker
Jan 25, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Elisabet Åkesson, Erik Sundström
Jan 25, 2007·Expert Opinion on Investigational Drugs·Martin Braddock
Jun 30, 2006·Expert Opinion on Biological Therapy·Damien D Pearse, David J Barakat
Jan 29, 2008·British Journal of Neurosurgery·S Knafo, D Choi
Jun 18, 2010·Brain Research Bulletin·George M Smith, Stephen M Onifer
May 25, 2010·Physical Medicine and Rehabilitation Clinics of North America·Susan CharlifueDaniel Lammertse
Jun 15, 2007·Journal of the Neurological Sciences·Florence M Bareyre
Jan 31, 2004·The European Journal of Neuroscience·Máté D Döbrössy, Stephen B Dunnett
Apr 5, 2008·Neurological Research·J Louro, D D Pearse
Oct 24, 1998·Experimental Neurology·M FraidakisC Spenger
Apr 7, 2005·Reviews in the Neurosciences·Màtè Daniel Döbrössy, Stephen B Dunnett
Aug 7, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·M Murray, I Fischer
Dec 6, 2001·Nature Reviews. Neuroscience·M D Döbrössy, S B Dunnett
Jul 22, 2006·Nature Reviews. Neuroscience·Sandrine ThuretFred H Gage
Sep 12, 2000·Neurosurgery·K Barami, F G Diaz
Nov 22, 2002·Advances in Physiology Education·Claire E Hulsebosch
Jan 24, 2002·Spine·B K Kwon, W Tetzlaff
Mar 17, 2001·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S D Christie, I Mendez
Nov 2, 2019·Nature Reviews. Neurology·Gergely DavidPatrick Freund
Jun 11, 2020·Nature Reviews. Neuroscience·Itzhak FischerMichael A Lane

❮ Previous
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