Obliterative airway remodelling in transplanted and non-transplanted lungs.

Virchows Archiv : an International Journal of Pathology
Danny JonigkFlorian Laenger

Abstract

Obliterative airway remodelling is a morphological sequence in a variety of pulmonary diseases. Notably, bronchiolitis obliterans represents one of the key complications of lung transplantation, induced by (immigrating) myofibroblasts. A comparative expression analysis of obliterative airway remodelling in transplanted and non-transplanted patients has not been reported so far. Obliterated and unremodelled airways from explanted lungs (n = 19) from patients suffering from chronic allograft dysfunction, infection, graft-versus-host disease and toxic exposure were isolated by laser-assisted microdissection. Airways from lung allografts harvested shortly before and after transplantation (n = 4) as well as fibroblastic foci from lungs with interstitial pulmonary fibrosis (n = 4) served as references. Pre-amplified cDNA was analysed by quantitative real-time RT-PCR for expression of fibrosis, inflammation and apoptosis-associated genes. Composition of infiltrating cells and protein expression were assessed by conventional histology and immunohistochemistry. Bronchiolitis obliterans in transplanted patients showed a significant increase of BMP-7 expression (p = 0.0141 compared with controls), while TGF-beta1 and FGF-2 as well as BMP-...Continue Reading

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Citations

Jul 12, 2011·Current Opinion in Pulmonary Medicine·Konstantinos Pappas
Jul 31, 2012·Respiratory Research·Travis MeutenPhilip L Sannes
May 25, 2012·Orphanet Journal of Rare Diseases·A-Rembert KoczullaSabina Janciauskiene
Oct 18, 2015·The American Journal of Pathology·Danny JonigkFlorian Laenger
Feb 2, 2011·The American Journal of Pathology·Danny JonigkFlorian Laenger
Jun 28, 2011·The American Journal of Pathology·Danny JonigkFlorian Laenger
Jun 11, 2016·Journal of Translational Medicine·Nicole IzykowskiDanny Jonigk
Nov 12, 2016·Cell and Tissue Research·Mark KuehnelDanny Jonigk
Oct 17, 2017·Experimental Lung Research·Marietta von Suesskind-SchwendiKarla Lehle
Aug 23, 2019·The Journal of Pathology. Clinical Research·Danny JonigkFlorian Laenger

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