Obliterative bronchiolitis: individual CT signs of small airways disease and functional correlation

Radiology
David M HansellA U Wells

Abstract

Individual features of small airways disease depicted at computed tomography (CT) were correlated with functional indexes in patients with obliterative bronchiolitis. Fifteen patients (all women) who fulfilled the strict criteria for diagnosis of obliterative bronchiolitis underwent thin-section CT at full inspiration and at end expiration. The CT scans were scored by two observers for extent of decreased attenuation of the lung parenchyma; end-expiration CT signs of air trapping; and bronchial dilation, wall thickening, and mucous plugging. The functional importance of each CT sign was evaluated. Areas of decreased attenuation were present in all patients (median score at end expiration, 61%; range, 21%-83%). Bronchial wall thickening was identified in 13 of the 15 patients. Correlations of the extent of decreased attenuation and measures of air-flow obstruction were strongest between decreased attenuation at end expiration and air flow at low lung volumes (r(s) = -.70, P < .005). This relationship remained intact after correction for the severity of bronchial wall thickening. In patients with obliterative bronchiolitis, the extent of decreased attenuation at CT was most strongly related to depression of pulmonary function tes...Continue Reading

Citations

May 24, 2005·Archives of Disease in Childhood·U G Rossi, C M Owens
Jun 30, 2007·Thorax·Jean-François Cordier
Dec 12, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J P MayberryN L Müller
Sep 21, 2012·Radiology·Maxime HackxPierre Alain Gevenois
Jan 20, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Shin MatsuokaHiroto Hatabu
Dec 10, 2014·Radiological Physics and Technology·Keiko MorikawaHiromu Mori
Jan 25, 2007·Radiology·Alexander A BankierPierre Alain Gevenois
May 30, 2002·Radiology·Susan J CopleyDavid M Hansell
Jul 19, 2003·Radiology·Francois ChabatDavid M Hansell
May 23, 2006·AJR. American Journal of Roentgenology·Winnie C W ChuAnil T Ahuja
Apr 18, 2002·AJR. American Journal of Roentgenology·Hiroaki ArakawaW Richard Webb
Jul 23, 2005·AJR. American Journal of Roentgenology·Sudhakar J PipavathJohn D Newell
Jun 13, 2008·International Archives of Occupational and Environmental Health·David Galbraith, David Weill
Mar 7, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ryoji ItoJitsuo Higaki
Jul 12, 2011·Revue des maladies respiratoires·F Laurent, M Tunon de Lara
Mar 1, 2010·Surgical Pathology Clinics·Timothy Craig Allen
Jul 14, 2010·European Journal of Radiology·Hiroaki ArakawaYasushi Kaji
Feb 13, 2008·Clinics in Chest Medicine·Felix WoodheadSujal R Desai
Aug 11, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Osman TemizozMustafa Kemal Demir
Jan 6, 2007·The Journal of Allergy and Clinical Immunology·José-Manuel Tunon-de-LaraPascal Chanez
Feb 3, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lisa M YoungMargaret L Wilsher
Jul 6, 2010·Clinical Radiology·K E HawtinS J Copley
Jul 12, 2003·Seminars in Roentgenology·Andetta R Hunsaker
Jan 15, 2002·Clinics in Chest Medicine·E H AlhamadF J Martinez
Nov 9, 2001·Radiologic Clinics of North America·D M Hansell
Jan 30, 2002·Radiologic Clinics of North America·Gayle M Waitches, Eric J Stern

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