PMID: 22338930Feb 22, 2012Paper

Observation: application and advantages of BMK in osteoporosis by monitoring the dose of antiresorptive drugs with CTx

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Sek Aksaranugraha

Abstract

One of the potential applications of BMK is the dynamic measure of bone metabolism. The present study aimed to observe the dynamic response of patients' bone toward the antiresorptive drugs by using BMK in the prospective procedure. The subjects were 309 Thai women. They were divided by age into 3 groups: A) 56 participants at 50-60 years old, B) 116 participants at 61-70 years old and C) 137 participants at over 71 years old. They had the blood BMK tests based on these conditions: 1) prior to the prescription of antiresorptive drugs, 2) every month for following up the administration of the drugs until the proper doses were obtained, 3) every 3 month after the proper doses were obtained. The patients were observed on the 5-category criteria resulting in as follows: Category 1: No previous history of antiresorptive drugs adminitration and the CTx level was lower than normal. The antiresorptive drugs were not required during this 2-year observation. There were 7 cases aged 50-60, 13 cases aged 61-70 and 16 cases aged 71 up. Category 2: No previous history of antiresorptive drugs administration but the CTx was higher than normal. Then the antiresorptive drugs were prescribed and the CTx later became lower than normal. Thereafter,...Continue Reading

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