Observation of coherent reaction dynamics in heme proteins

L ZhuPaul M Champion


Femtosecond laser pulses, resonant with Soret band of the nitric oxide complex of myoglobin (MbNO), were used to probe coherent, low-frequency nuclear motion of the heme group after photolysis. Distinct oscillations with periods of 430 and 150 femtoseconds were observed and are attributed to heme doming and iron-histidine motion, respectively. These results verify that the nuclear motion of the heme is strongly coupled to the ligand binding reaction and demonstrate that such motion is not determined by overdamped (diffusive) dynamics. The relative phases and frequencies of the nuclear motion of the photoproduct suggest that the coherence arises from impulsive electronic forces associated with the spin-state change of the heme iron atom and the depopulation of its dz2 orbital during the bond-breaking event.


Apr 1, 2004·Journal of the American Chemical Society·Bogdan M LeuJ Timothy Sage
Apr 21, 2005·Journal of the American Chemical Society·Xiong YePaul M Champion
Dec 1, 2005·Journal of the American Chemical Society·Dan IonascuPaul M Champion
Jul 4, 2008·Journal of the American Chemical Society·Minoru KuboPaul M Champion
Feb 11, 2009·Journal of the American Chemical Society·Chen ZangDongping Zhong
Jul 11, 2009·The Journal of Physical Chemistry. B·Zhenyu ZhangPaul M Champion
Feb 17, 2010·The Journal of Physical Chemistry. B·Venugopal KarunakaranPaul M Champion
Oct 1, 1996·Nature Structural Biology·W R CannonS J Benkovic
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sergei G KruglikMichel Negrerie
Nov 15, 2005·Science·Paul M Champion
Feb 20, 2008·Biochemistry. Biokhimii︠a︡·A N OsipovYu A Vladimirov
Nov 16, 2006·Annual Review of Physical Chemistry·Philipp KukuraRichard A Mathies
Jul 13, 2011·The Journal of Chemical Physics·Alexander BarabanschikovE Ercan Alp
Dec 11, 2007·The Journal of Chemical Physics·Ryosuke NakamuraYasuo Kanematsu
Apr 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergei G KruglikMarten H Vos
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·D Zhong, A H Zewail
Jul 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Breland G OscarChong Fang
Sep 19, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Majed Chergui
Feb 18, 2014·Inorganic Chemistry·Jeffrey W PavlikW Robert Scheidt
Dec 10, 2014·Journal of the American Chemical Society·Jianfeng LiW Robert Scheidt
Apr 28, 2010·Angewandte Chemie·Jeffrey W PavlikW Robert Scheidt
Mar 22, 2016·Chemistry : a European Journal·Qian PengW Robert Scheidt
Mar 14, 2007·Biophysical Journal·Bogdan M LeuJ Timothy Sage
Aug 12, 2015·The Journal of Physical Chemistry. a·M LiebelP Kukura
Aug 13, 2015·The Journal of Physical Chemistry Letters·So Young Kim, Taiha Joo
Jan 23, 2016·Structural Dynamics·M LevantinoM Cammarata
Apr 27, 1999·Biochimica Et Biophysica Acta·M H Vos, J L Martin
Nov 13, 2007·Biochimica Et Biophysica Acta·Marten H Vos
Feb 6, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Giulio CerulloDario Polli
May 28, 2016·The Journal of Physical Chemistry. B·Yuhan SunPaul M Champion
Jul 1, 2016·The Journal of Physical Chemistry. a·Zhenkun GuoAndrew M Moran
Aug 9, 2016·The Journal of Chemical Physics·Alexander SchubertChristoph Meier
Jul 19, 2013·The Journal of Physical Chemistry. B·Yuhan SunPaul M Champion
Jun 3, 2011·The Journal of Physical Chemistry. B·Kevin L Dillman, Warren F Beck
Feb 24, 2017·Physical Chemistry Chemical Physics : PCCP·Sean R TachibanaChong Fang

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.