Observation of hyperpositive non-linear effect in catalytic asymmetric organozinc additions to aldehydes

Chirality
Yannick GeigerStephane Bellemin-Laponnaz

Abstract

Asymmetric amplification is a phenomenon that is believed to play a key role in the emergence of homochirality in life. In asymmetric catalysis, theoretical and experimental models have been investigated to provide an understanding of how chiral amplification is possible, in particular based on non-linear effects. Interestingly, it has been proposed a quarter century ago that chiral catalysts, when not enantiopure might even be more enantioselective than their enantiopure counterparts. We show here that such hyperpositive non-linear effect in asymmetric catalysis is indeed possible. An in-depth study into the underlying mechanism was carried out, and the scheme we derive differs from the previous proposed models.

References

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Dec 31, 2008·Angewandte Chemie·Tummanapalli SatyanarayanaHenri B Kagan
Sep 21, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Donna G Blackmond
Apr 1, 1986·Journal of the American Chemical Society·C PuchotH B Kagan

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Citations

Jun 8, 2021·Chemical Science·Yannick GeigerStéphane Bellemin-Laponnaz

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