Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Xiaoling ZhouNong Tang

Abstract

Bone marrow mesenchymal stem cells (BMSCs) transplantation has attracted attention for the treatment of liver cirrhosis and end-stage liver diseases. Therefore, in this study, we evaluated the effect of different methods of BMSCs transplantation in the treatment of liver cirrhosis in rats. Seventy-two male Sprague-Dawley rats were divided into 7 groups: 10 were used to extract BMSCs, 10 were used as normal group, and the remaining 52 rats were randomly divided into five groups for testing: control group, BMSCs group, BMSCs+granulocyte colony-stimulating factor (G-CSF) group, and BMSCs+Jisheng Shenqi decoction (JSSQ) group. After the end of the intervention course, liver tissue sections of rats were subjected to hematoxylin and eosin (H&E) and Masson staining, and pathological grades were scored. Liver function [aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB)] and hepatic fibrosis markers [hyaluronidase (HA), laminin (LN), type III procollagen (PCIII), type IV collagen (CIV)] were measured. BMSCs+JSSQ group had the best effect of reducing ALT and increasing ALB after intervention therapy (P<0.05). The reducing pathological scores and LN, PCIII, CIV of BMSCs+G-CSF group and BMSCs+JSSQ group after intervent...Continue Reading

References

Jun 11, 2005·World Journal of Gastroenterology : WJG·Dong-Chang ZhaoPeng Xiang
Jul 31, 2007·World Journal of Gastroenterology : WJG·Mehdi MohamadnejadHossein Baharvand
Sep 18, 2007·Biochemical and Biophysical Research Communications·Biju ParekkadanMartin L Yarmush
Mar 9, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Bruno C HuberWolfgang-Michael Franz
Dec 17, 2011·Journal of Hepatology·Tatiana Kisseleva, David A Brenner
Jan 10, 2012·Pharmacognosy Research·Anil U TatiyaNehal H Gamit
Mar 15, 2012·World Journal of Gastroenterology : WJG·Wei ZhaoKe-Feng Dou
Jun 7, 2014·Frontiers in Immunology·Elke EggenhoferMartin J Hoogduijn
Mar 2, 2016·The Journal of Thoracic and Cardiovascular Surgery·Masaya SugimotoHideaki Senzaki
Nov 11, 2017·Przegla̜d gastroenterologiczny·Monika GudowskaLech Chrostek
Feb 2, 2018·Journal of Digestive Diseases·Rilu FengHong-Lei Weng
Mar 6, 2018·Journal of Cosmetic Dermatology·Mohammad-Reza Mahmoudian-SaniMassoud Saidijam

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BETA
biopsies

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