Observation of the treatment and outcomes of patients receiving chemotherapy for advanced NSCLC in Europe (ACTION study)

Current Medical Research and Opinion
Helge G BischoffNicholas Thatcher

Abstract

The ACTION (Assessment of Cost and ouTcomes of chemotherapy In an Observational setting) study investigated associations between chemotherapy, patient/disease characteristics and outcomes in advanced non-small cell lung cancer (NSCLC) patients in clinical practice. Chemonaïve NSCLC patients from five European countries were observed for 18 months from initiation of first-line chemotherapy; care was at the physician's discretion. Survival and associated prognostic factors were estimated using Kaplan-Meier methods and a Cox proportional hazards model, respectively. Cluster analyses of baseline patient characteristics were also performed. Toxicity data were not considered in these analyses. A total of 975 eligible patients with NSCLC (Stage IIIb/IV) were enrolled and provided baseline and response data; cluster analysis was performed on 829 patients and survival data were available from 906 patients. In first-line treatment, a 39.8% response rate, a 39.5% 1-year survival rate and unadjusted median survival of 9.3 months were observed. Prognostic factors for survival included performance status (PS), number of metastatic organs, gender and age. Five patient clusters were identified, highlighting patient heterogeneity in terms of ba...Continue Reading

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Citations

Jun 22, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christos ChouaidPaul L R Mitchell
Apr 1, 2014·Revue des maladies respiratoires·F Chermiti Ben AbdallahA Ben Kheder
Mar 25, 2017·Expert Review of Pharmacoeconomics & Outcomes Research·Jacqueline BrownAnita Chawla

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