Observation on the integrity of the blood-brain barrier after microbubble destruction by diagnostic transcranial color-coded sonography

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Felix SchlachetzkiU Bogdahn

Abstract

To investigate alteration of the blood-brain barrier from ultrasonic contrast agent destruction by diagnostic transcranial color-coded sonography using gadolinium-enhanced magnetic resonance imaging. Healthy male volunteers received 10 mL (400 mg/dL) of Levovist (SH U 508A; Schering AG, Berlin, Germany; n = 6) or 3 mL of Optison (FS069; Mallinckrodt Inc, St Louis, MO; n = 4) followed by 0.3 mmol/kg magnetic resonance imaging contrast agent (Magnevist; Schering) intravenously. Then transcranial color-coded sonography was performed with a conventional color duplex sonographic system, which insonated the brain in a slightly angulated axial plane with temporal average intensity of less than 700 mW/cm2 or acoustic pressure amplitude of less than 2.69 MPa, attenuated by the temporal bone. Before, immediately after, and 2 hours after insonation, T1-weighted axial magnetic resonance imaging was performed. All magnetic resonance images were individually assessed, and T1 signal intensities were measured in 2 regions of interest in both hemispheres at the 3 time points. No focal contrast enhancement or damage to the brain and no significant difference between T1 signal intensities in the right and left brain regions could be detected duri...Continue Reading

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Citations

Sep 21, 2007·Expert Opinion on Drug Delivery·Joseph L Bull
Sep 19, 2007·Der Radiologe·M Krix, J W Jenne
Oct 14, 2016·Biomechanics and Modeling in Mechanobiology·Wolfgang WiedemairVartan Kurtcuoglu
Jan 26, 2017·Health Physics·UNKNOWN International Commission on Non-Ionizing Radiation Protection (ICNIRP)
Mar 14, 2009·Medical & Biological Engineering & Computing·Stephen MeairsMichael Hennerici
Sep 24, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Olivia C CoiadoWilliam D O'Brien
Jul 8, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuhiko KobayashiMuneyasu Saito
Mar 25, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Douglas L MillerJunru Wu
Jul 15, 2009·Medical & Biological Engineering & Computing·Gail ter Haar
Sep 9, 2006·Progress in Biophysics and Molecular Biology·Stephen Meairs, Angelika Alonso
Aug 29, 2006·Progress in Biophysics and Molecular Biology·William D O'Brien

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