PMID: 20626147Jul 16, 2010Paper

Observation on the therapeutic effect of electroacupuncture combined with small dose of clozapine in clinical treatment of refractory schizophrenia

Zhen ci yan jiu = Acupuncture research
Dian-zhang Xiong Ye-Feng

Abstract

To observe the effect of electroacupuncture (EA) in combination with small dose of clozapine on clinical symptoms of refractory schizophrenia patients so as to evaluate its validity and security. Eighty schizophrenia patients were randomized into medication group and EA + medication group (n=40/group). Patients of medication group were treated with conventional oral administration of clozapine (50-100 mg/d to 200-500 mg/d, for 8 weeks) and those of EA + medication group treated by EA of Baihui(GV 20) and bilateral Taiyang (EX-HN 5) and oral administration of clozapine (50 mg/d to 100-150 mg/d). EA was given to the patients, 3 times a week for 8 weeks. Scores of the Positive and Negative Symptom Scale (PANSS) and the Untoward Effect Symptom Scale (TESS) were used to assess the therapeutic effect. Following treatment, PANSS scores for positive symptoms and the common psychiatric symptoms of the medication and EA + medication groups all decreased evidently from the 2rd week on (P < 0.05, P < 0.01), and those of the negative symptoms reduced obviously from the 4th week on (P < 0.05). Comparison between two groups showed no significant differences in PANSS scores for positive and negative symptoms and the common psychiatric symptoms...Continue Reading

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