Observational clinical study on the effects of different dosing regimens on vancomycin target levels in critically ill patients: Continuous versus intermittent application

Journal of Infection and Public Health
S TafelskiABx Study Group

Abstract

Different dosing regimens for vancomycin are in clinical use: intermittent infusion and continuous administration. The intention of using these different dosing regimens is to reduce toxicity, to achieve target levels faster and to avoid treatment failure. The aim of this phase IV study was to compare safety and effectiveness in both administration regimens. The study was conducted in 2010 and 2011 in three postoperative intensive care units (ICUs) in a tertiary care university hospital in Berlin, Germany. Adult patients with vancomycin therapy and therapeutic drug monitoring were included. Out of 675 patients screened, 125 received vancomycin therapy, 39% with intermittent and 61% with continuous administration. Patients with continuous administration achieved target serum levels significantly earlier (median day 3 versus 4, p=0.022) and showed fewer sub-therapeutic serum levels (41% versus 11%, p<0.001). ICU mortality rate, duration of ICU stay and duration of ventilation did not differ between groups. Acute renal failure during the ICU stay occurred in 35% of patients with intermittent infusion versus 26% of patients with continuous application (p=0.324). In conclusion, continuous administration of vancomycin allowed more ra...Continue Reading

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Citations

Dec 15, 2015·International Journal of Antimicrobial Agents·Jing-Jing HaoJian-Xin Zhou
Oct 27, 2016·Biochemical Pharmacology·Çiğdem Yılmaz, Gülay Özcengiz
Aug 30, 2018·Pharmacology Research & Perspectives·Joaquim F MonteiroPaula Fresco
Sep 19, 2015·Current Opinion in Infectious Diseases·Suzanne L ParkerJason A Roberts
Apr 13, 2018·Journal of Intensive Care Medicine·Brittany D BissellChristopher Morrison

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