Observational cohort study of pediatric inpatients with central venous catheters at "intermediate risk" of thrombosis and eligible for anticoagulant prophylaxis

Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses
Kathy M HarneyEllis J Neufeld

Abstract

The risk of deep vein thrombosis (DVT) among hospitalized children is rising.The optimal approach to DVT prophylaxis in children is unclear. This study set out to ascertain the prevalence of DVT among pediatric inpatients who neither have contraindications to nor absolute indications for prophylactic therapy. A prospective surveillance of at-risk children plus a retrospective chart review were conducted. Patients were considered to be at risk after the first 2 days of their admission. Of 1,637 patients reviewed, 198 patients met criteria; among these, 84% did not receive prophylaxis. Of 2,354 observed days at risk for nonprophylaxed patients (including days at risk prior to initiating prophylaxis among prophlyaxed patients), there were 9 DVT events, for a rate 3.82/1,000 days observed. A total of 31 patients received prophylaxis. Three of these patients experienced a DVT. One patient had a bleeding event, hematuria. These results describe patients who may be eligible for prophylaxis and should be screened for further risk factors.

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Citations

Oct 26, 2010·Seminars in Oncology Nursing·Terrah L FosterPamela S Hinds
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Reineke A SchootCornelia H van Ommen
Dec 20, 2013·Critical Care Medicine·Edward Vincent S FaustinoUNKNOWN PROphylaxis against ThRombosis prACTice (PROTRACT) Study Investigators of the PALISI BloodNet
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Leonardo R BrandãoPrakeshkumar S Shah
Jun 20, 2020·The Cochrane Database of Systematic Reviews·Marie-Claude Pelland-MarcotteLeonardo R Brandão

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