Observational outcomes in proliferative diabetic retinopathy patients following treatment with ranibizumab, panretinal laser photocoagulation or combination therapy - The non-interventional second year follow-up to the PRIDE study.

Acta Ophthalmologica
Gabriele E LangSandra Liakopoulos

Abstract

Ranibizumab monotherapy showed stronger effects on area of retinal neovascularization (NV) reduction while offering better visual acuity (VA) results than panretinal laser photocoagulation (PRP) monotherapy during the first 12 months of the PRIDE study. The second year of PRIDE was an observational, non-interventional follow-up, performed to evaluate long-term anatomical and functional outcomes in proliferative diabetic retinopathy (PDR) patients under real-life conditions, prior to the approval of ranibizumab for PDR. Seventy-three PDR patients (28 from the ranibizumab group; 20 from the PRP group; 25 from the combination group) were included in the observational follow-up phase and treated at the investigators discretion. Visual acuity (VA) measurements and retinal imaging were performed at Months 12, 18 and 24. Mean (± SD) NV area in the ranibizumab monotherapy and combination follow-up groups increased from 3.16 ± 4.30 mm2 and 1.13 ± 2.78 mm2 at Month 12 to 6.09 ± 10.79 mm2 and 2.14 ± 4.41 mm2 at Month 18 and 10.00 ± 17.63 mm2 and 3.26 ± 7.05 mm2 at Month 24, respectively. In the PRP follow-up group, NV area declined from 5.44 ± 14.55 mm2 at Month 12 to 1.22 ± 1.67 mm2 at Month 18, but increased again to 4.05 ± 11.66 mm2 at...Continue Reading

References

Feb 8, 2011·Acta Ophthalmologica·Aysha SalamSobha Sivaprasad
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Jul 4, 2012·The American Journal of Pathology·Leo A Kim, Patricia A D'Amore
Nov 14, 2015·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Committee for the Diabetic Retinopathy Clinical Research NetworkRoy W Beck
Nov 26, 2015·Eye and Vision·Ryan LeeCharumathi Sabanayagam
Dec 3, 2015·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·João FigueiraJosé Cunha-Vaz
Jul 26, 2018·JAMA Ophthalmology·Jeffrey G GrossUNKNOWN Diabetic Retinopathy Clinical Research Network
May 21, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·UNKNOWN Deutsche Ophthalmologische Gesellschaft (DOG)UNKNOWN Berufsverband der Augenärzte Deutschlands e. V. (BVA)

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