Observational Retrospective Study of Altered Biodistribution of Tositumomab and 131I-Tositumomab

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Richard L WahlMark S Kaminski

Abstract

The tositumomab/(131)I-tositumomab radioimmunotherapy regimen is administered as a dosimetric dose followed by a therapeutic dose. The biodistribution of the dosimetric dose is assessed by quantitative calculations of whole-body residence time (TBRT) and visual examination of whole-body γ-camera images, to determine the administered radioactivity dose and whether a therapeutic dose can be administered. We investigated whether altered biodistribution of (131)I-tositumomab could be identified using quantitative TBRT. BioClinica, Inc., provided γ-camera images to an independent reviewer to assess altered (131)I-tositumomab biodistribution in patients reported to a registry. Of 2,649 therapeutic doses, 5 (0.2%) were cancelled because of altered biodistribution as determined by γ-camera images and TBRT. Of these, 3 γ-camera images were assessed by the independent reviewer; one showed altered biodistribution (0.04%) and was in agreement with the TBRT on-site calculation. TBRT alone should be used to determine altered biodistribution and hence whether to administer the therapeutic dose.

References

Oct 21, 1993·The New England Journal of Medicine·O W PressB Porter
Oct 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S KaminskiJ M Vose
Feb 4, 2005·The New England Journal of Medicine·Mark S KaminskiRichard L Wahl
Jun 11, 2011·Best Practice & Research. Clinical Haematology·Tim Illidge, Franck Morschhauser

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