Observational study of chronic myeloid leukemia Italian patients who discontinued tyrosine kinase inhibitors in clinical practice

Haematologica
Carmen FavaGiuseppe Saglio

Abstract

It is judged safe to discontinue treatment with tyrosine kinase inhibitors (TKI) for chronic myeloid leukemia (CML) in experimental trials on treatment-free remission (TFR). We collected a total of 293 Italian patients with chronic phase CML who discontinued TKI in deep molecular response. Seventy-two percent of patients were on treatment with imatinib, and 28% with second generation TKI at the time of discontinuation. Median duration of treatment with the last TKI was 77 months [Interquartile Range (IQR) 54;111], median duration of deep molecular response was 46 months (IQR 31;74). Duration of treatment with TKI and duration of deep molecular response were shorter with second generation TKI than with imatinib (P<0.001). Eighty-eight percent of patients discontinued as per clinical practice, and reasons for stopping treatment were: toxicity (20%), pregnancy (6%), and shared decision between treating physician and patient (62%). After a median follow up of 34 months (range, 12-161) overall estimated TFR was 62% (95%CI: 56;68). At 12 months, TFR was 68% (95%CI: 62;74) for imatinib, 73% (95%CI: 64;83) for second generation TKI. Overall median time to restart treatment was six months (IQR 4;11). No progressions occurred. Although o...Continue Reading

Citations

Feb 15, 2020·British Journal of Haematology·Giuseppe Saglio, Robert P Gale
Jun 6, 2020·Journal of Clinical Medicine·Domenico RussoMichele Baccarani
Aug 29, 2019·Frontiers in Oncology·Maria Stella PennisiPaolo Vigneri
Jul 25, 2019·Frontiers in Oncology·Valentín García-Gutiérrez, Juan Carlos Hernández-Boluda
Oct 13, 2020·Hematology Reports·Matteo MolicaElisabetta Abruzzese
Jan 14, 2021·World Journal of Clinical Oncology·Ruth StuckeyMaría Teresa Gómez-Casares
Nov 7, 2020·Leukemia & Lymphoma·Vashti N M F TrompJacqueline G Hugtenburg
Aug 28, 2021·Cancers·Hilbeen Hisham Saifullah, Claire Marie Lucas

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