Observational study of coagulation activation in early breast cancer: development of a prognostic model based on data from the real world setting

Journal of Translational Medicine
Chiara MandojMaddalena Barba

Abstract

Cancer and coagulation activation are tightly related. The extent to which factors related to both these pathologic conditions concur to patient prognosis intensely animates the inherent research areas. The study herein presented aimed to the development of a tool for the assessment and stratification of risk of death and disease recurrence in early breast cancer. Between 2008 and 2010, two hundreds thirty-five (N: 235) patients diagnosed with stage I-IIA breast cancer were included. Data on patient demographics and clinic-pathologic features were collected in course of face-to-face interviews or actively retrieved from clinical charts. Plasma levels of plasminogen activator inhibitor type 1 (PAI-1), fragment 1 + 2 (F1 + 2), thrombin antithrombin complex (TAT), factor VIII (FVIII), and D-dimer (DD) were measured at breast cancer diagnosis and prior to any therapeutic procedure, including breast surgery. The risk of death was computed in terms of overall survival (OS), which was the primary outcome. For a subset of patients (N = 62), disease free survival (DFS) was also assessed as a measure of risk of disease recurrence. Median follow up was 95 months (range 6-112 months). Mean age at diagnosis was 60.3 ± 13.4 years. Cancer cas...Continue Reading

References

Feb 12, 2005·Seminars in Thrombosis and Hemostasis·Anna Falanga
Aug 18, 2005·British Journal of Cancer·L M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Feb 8, 2006·Journal of Thrombosis and Haemostasis : JTH·J W BlomF R Rosendaal
Mar 1, 2006·Archives of Internal Medicine·Helen K ChewRichard H White
Dec 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helen K ChewRichard H White
May 22, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·G AltiayT Caglar
Dec 3, 2008·European Journal of Internal Medicine·Engin YigitBurcu Cakar
Apr 25, 2009·Cancer Investigation·Ted Wun, Richard H White
Mar 31, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Emilio BriaFrancesco Facciolo
Aug 18, 2009·The American Journal of Medicine·Alexander P ReinerAndrea Z LaCroix
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alok A Khorana, Gregory C Connolly
Apr 23, 2010·British Journal of Cancer·S Noble, J Pasi
May 1, 2013·Seminars in Thrombosis and Hemostasis·Mandy N LauwHarry R Buller
Apr 1, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M AlexanderK Burbury
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joleen M HubbardHyman B Muss
Mar 11, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Manabu SakuraiHiroyuki Yoshikawa
Apr 24, 2015·Thrombosis Research·Anna FalangaLaura Russo
Oct 27, 2015·JAMA Oncology·Diana L MigliorettiUNKNOWN Breast Cancer Surveillance Consortium
Jan 1, 2016·Critical Reviews in Oncology/hematology·Jacques BernierJean-Claude Horiot
Oct 19, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hee Kyung KimYeon Hee Park
Jun 2, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Catherine L CallahanJo L Freudenheim
Nov 25, 2016·Expert Review of Anticancer Therapy·Matteo LambertiniEvandro de Azambuja
Apr 27, 2017·Endocrine-related Cancer·Ana B CrujeirasManel Esteller
Jun 1, 2017·The New England Journal of Medicine·Norikazu MasudaMasakazu Toi
Aug 15, 2017·Breast Cancer Research and Treatment·M LodiC Mathelin
Sep 18, 2017·Critical Reviews in Oncology/hematology·Anna FalangaAlfonso Vignoli
Dec 3, 2017·International Journal of Cancer. Journal International Du Cancer·Pierre-Antoine DuguéRoger L Milne
Dec 7, 2017·The Lancet Oncology·Alice Y HoEdwin G Wilkins
Dec 30, 2017·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Software
SPSS
R

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
A SagripantiC Mittermayer
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
C. TecimerJ. L. Wittliff
© 2022 Meta ULC. All rights reserved