Observational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study

Cerebrovascular Diseases
Brian B KooH Klar Yaggi

Abstract

Wake-up stroke (WUS) accounts for a quarter of all ischemic strokes. Its conspicuous occurrence during sleep suggests that WUS may be associated with obstructive sleep apnea (OSA). We investigated the potential association among WUS, OSA, and measures of sympathetic hyperactivity. This is a cross-sectional analysis of data from the Sleep Apnea in Transient Ischemic Attack and Stroke (SLEEP TIGHT) study. Ischemic stroke patients were divided into WUS and non-WUS groups. Participants underwent polysomnography and ambulatory blood pressure monitoring. Collected data included demographic, medical, stroke characteristics (including severity by National Institutes of Health Stroke Scale), cholesterol, serum catecholamines, C-reactive protein, interleukin-6, B-type natriuretic peptide, blood pressure, and polysomnographic (apnea-hypopnea index (AHI); measures of hypoxia). Because both stroke and OSA affect men and women to varying degrees, the cohort was considered as a whole and by gender stratification. Among 164 participants, 30.3% had WUS. The mean age was 62.0 ± 11.3 and the mean body mass index was 30.2 ± 7.9 kg/m2. One-hundred-and-five participants (63.6%) were males and 92 participants (56.8%) were Caucasian. Neither AHI nor O...Continue Reading

Citations

Feb 6, 2017·Continuum : Lifelong Learning in Neurology·John W Cole
Jul 26, 2017·Critical Pathways in Cardiology·Emad F AzizEyal Herzog
Mar 23, 2018·Journal of Neurology·Zijian XiaoMingyong Li
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May 3, 2019·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Honghao ManZhaoqiang Zhang
Sep 13, 2019·CNS Spectrums·Mohamed ElfilBrian B Koo
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Jan 11, 2020·Sleep & Breathing = Schlaf & Atmung·Jacob CollenAaron Holley
Jul 17, 2020·Journal of Neurology·Yu-Lei ZhangYun-Cheng Wu
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