Observational study of switching anti-TNF agents in ankylosing spondylitis and psoriatic arthritis versus rheumatoid arthritis.

Wiener medizinische Wochenschrift
Guenther HaberhauerPeter Fasching

Abstract

Anti-TNF agents like infliximab, etanercept and adalimumab are efficacious in the treatment of ankylosing spondylitis (AS), psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Lack of efficacy, side effects and loss of efficacy over time may be reasons for switching to a second anti-TNF agent and sometimes switching to a third anti-TNF agent may be useful. Effects of switching may be different in patients with AS, PsA and RA. We analysed data of 301 patients with rheumatic diseases treated with anti-TNF agents. Forty-six patients had AS, 63 PsA and 192 RA. Totally 38% of these patients received more than one anti-TNF agent. Switching to a second anti-TNF agent was necessary in 115 (38%) of our patients, in detail in 11 of our AS patients, in 21 of PsA patients and in 83 of RA patients. Patient with PsA showed the best response rate to the second anti-TNF agent. Finally, 46 patients, 5 with SPA, 3 with PsA and 38 with RA received a third anti-TNF agent. We conclude that anti-TNF switching in AS and PsA is less frequent than in RA patients. Survival of anti-TNF agents in AS (p = 0.025) and also in PsA (n.s., p = 0.215) seems to be better than in RA. Switching anti-TNF agents for loss of efficacy over time may have the best e...Continue Reading

References

Jun 25, 2005·Annals of the Rheumatic Diseases·S N NikasA A Drosos
Mar 2, 2006·Arthritis Research & Therapy·Juan J Gomez-ReinoUNKNOWN BIOBADASER Group
Jul 14, 2006·Annals of the Rheumatic Diseases·Florenzo IannoneUNKNOWN GISEA (Gruppo Italiano per lo Studio delle Early Arthritis)
May 1, 2007·Arthritis and Rheumatism·Axel FinckhUNKNOWN Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis
Sep 11, 2008·Rheumatology·D J PradeepC Harris

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Citations

Jul 16, 2010·Wiener medizinische Wochenschrift·Peter Fasching
Aug 13, 2014·Advances in Therapy·Marcello GovoniMaurizio Rossini
Nov 13, 2015·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Oct 1, 2013·Expert Opinion on Biological Therapy·Denis Poddubnyy, Martin Rudwaleit
May 1, 2012·The American Journal of the Medical Sciences·Lianne GenslerAtul Deodhar
Jul 29, 2011·Reumatología clinica·Jose Luis Fernández SueiroUNKNOWN Sociedad Española de Reumatología [Spanish Society of Rheumatology]
Jan 1, 2015·Arthritis Research & Therapy·Adrian CiureaUNKNOWN Rheumatologists of Swiss Clinical Quality Management Program for Axial Spondyloarthritis
Sep 21, 2013·Revista brasileira de reumatologia·Sueli CarneiroPercival Degrava Sampaio-Barros
Sep 21, 2013·Revista brasileira de reumatologia·Percival Degrava Sampaio-BarrosCélio Roberto Gonçalves
Apr 24, 2018·Expert Opinion on Biological Therapy·Alexis JonesPedro M Machado
Sep 14, 2011·Nature Reviews. Rheumatology·Caroline A ChangPaul F Lizzul
Mar 17, 2020·Advances in Rheumatology·Gustavo Gomes ResendePercival Degrava Sampaio-Barros
Apr 2, 2017·Seminars in Arthritis and Rheumatism·Joseph F MerolaElinor A Mody

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