Observational study on the beneficial effect of preoperative statins in reducing atrial fibrillation after coronary surgery

The Annals of Thoracic Surgery
Giovanni MariscalcoAndrea Sala

Abstract

Recent evidence supports the important role of inflammation in atrial fibrillation (AF) after coronary artery bypass grafting (CABG) and there is growing evidence that statin has cardiac antiarrhythmic effects. The aim of this study was to assess the efficacy of preoperative statins in preventing AF after CABG in a longitudinal observational study. Over a two-year period, 405 consecutive patients underwent isolated CABG procedures. Univariate analysis was performed exploring the relationship regarding statin use and AF development. A propensity score for treatment with statins was obtained from core patient characteristics. The role of statin therapy on postoperative AF was assessed by means of a conditional logistic model, while stratifying on the quintiles of the propensity score. All analysis was performed retrospectively. Postoperative AF occurred in 29.5% of the patients with preoperative statin therapy compared with 40.9% of those patients without it (p = 0.021). No statistical differences among development of AF and type, dose, or duration of preoperative statin therapy were observed. Preoperative statins were associated with a 42% reduction in risk of AF development after CABG surgery (odds ratio [OR] 0.58, 95% confiden...Continue Reading

References

Jan 26, 2012·Journal of Anesthesia·Takeshi Omae, Yuichi Kanmura
Feb 26, 2011·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·R J FolkeringaH J G M Crijns
Apr 9, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elmar W KuhnThorsten Wahlers
Jan 29, 2009·European Heart Journal·Diana KaireviciuteGregory Y H Lip
Oct 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Qiang JiLiangjie Chi
Jul 14, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi KinoshitaKeiji Matsubayashi
Oct 25, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Giovanni MariscalcoAndrea Sala
Jul 11, 2009·Vascular Health and Risk Management·Hadi Ar HadiSamer Ellahham
Nov 26, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Abhimanyu BeriSnigdha B Mahajan
Dec 18, 2009·Future Cardiology·Khaja S MohammedSimone Musco
Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Hiroaki SakamotoMasataka Satou
Aug 14, 2009·Expert Opinion on Drug Safety·Alexander Kulik, Marc Ruel
Sep 3, 2013·The Annals of Thoracic Surgery·Elmar W KuhnThorsten Wahlers
Mar 13, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masamichi Hirose, Naoko Matsushita
Jan 26, 2011·Journal of Clinical Lipidology·Yi Lin LeeSteven R Jones
Nov 16, 2010·Anesthesiology Clinics·Phillip L KalarickalAlan D Kaye
Jul 14, 2010·The Journal of Thoracic and Cardiovascular Surgery·Antonios KourliourosMarjan Jahangiri
May 4, 2010·The Journal of Thoracic and Cardiovascular Surgery·Jeanne ShenRichard B Schuessler
Jun 22, 2010·Heart & Lung : the Journal of Critical Care·Phillip J TullyHelen R Winefield
Aug 25, 2009·The Journal of Thoracic and Cardiovascular Surgery·Oliver J LiakopoulosThorsten Wahlers
Jun 30, 2009·The Annals of Thoracic Surgery·Amedeo AnselmiMario Gaudino
Sep 25, 2007·The Annals of Thoracic Surgery·Lawrence L Creswell
Oct 30, 2010·Pacing and Clinical Electrophysiology : PACE·Leonardo CalòFrancesco Fedele
May 16, 2013·Scandinavian Journal of Immunology·K T LappegårdT E Mollnes
Jan 7, 2014·European Journal of Clinical Investigation·Kirolos A JacobDiederik van Dijk
Jun 3, 2008·American Heart Journal·Maciej BanachJacek Rysz
Jan 25, 2011·The Annals of Thoracic Surgery·Salima MithaniSelcuk Adabag
Mar 4, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe PattiKausik K Ray
Mar 21, 2017·The Annals of Thoracic Surgery·Michael CurtisWei Pan
Dec 17, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Kurt ReinhartMelanie Ley-Wah Siv
May 25, 2016·The Cochrane Database of Systematic Reviews·Elmar W KuhnOliver J Liakopoulos
Jan 17, 2008·The Annals of Pharmacotherapy·Patricia A Howard, Brian J Barnes
Mar 11, 2018·Journal of Anesthesia·Takeshi Omae, Eiichi Inada

Citations

Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S A NashefR Salamon
Nov 14, 2000·The American Journal of Cardiology·M I DotaniC M Gibson
Feb 20, 2003·European Heart Journal·P O BonettiA Lerman
Dec 1, 1954·Circulation·J E RISEMANG E ALTMAN
Dec 17, 2003·The American Journal of Cardiology·Yinong Young-XuShmuel Ravid
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Joseph P MathewMulticenter Study of Perioperative Ischemia Research Group
Jun 1, 2005·Vascular Pharmacology·Douglas G Wright, David J Lefer
Oct 13, 2005·Statistics in Medicine·Peter C Austin, Muhammad M Mamdani
Dec 27, 2005·The American Journal of Cardiology·Francisco MarínMariano Valdés
Mar 1, 2006·Critical Care Medicine·Massimo ChelloElvio Covino
May 3, 2006·The Journal of Surgical Research·E Victor TselentakisAdam E Saltman
May 31, 2006·The Journal of Thoracic and Cardiovascular Surgery·Giovanni MariscalcoAndrea Sala
Jul 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Charles D CollardIschemia Research and Education Foundation (IREF) Investigators
Oct 26, 2006·The Annals of Thoracic Surgery·Colleen Gorman KochEugene H Blackstone

Related Concepts

Calcium [EPC]
Kidney Failure
Calcium
Amiodarone
Discipline of Heart Surgery
Anti-Arrhythmia Agents
Recurrent Malignant Neoplasm
Myocardium
Antiarrhythmic [EPC]
Hospital Mortality

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.